CHARACTERIZATION OF AMINOINDAMINES AND AMINOINDOANILINES FORMED BY OXIDATIVE HAIR DYEING AND THEIR MUTAGENICITY
スポンサーリンク
概要
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2-Amino-5-methoxy-2'(or 3')-methylindamine and 2-amino-5-methoxy-2'(or 3')-methylindoaniline were isolated from a coloring matter formed by oxidative condensation of 2,5-diaminotoluene with 2,4-diaminoanisole, and their structures were elucidated on the basis of nuclear magnetic resonance and mass spectral data. These two main components of the oxidation product formed at the early stage exhibited a positive result in the mutagenicity test on the thin-layer chromatography plate. The mutagenic activities of purified aminoindamines and aminoindoanilines against Salmonella typhimurium TA 98 were as strong as that of 2-acetamidofluorene. It was also demonstrated that 5-methoxy-2'(or 3')-methylindamine was formed in 10% yield under the conditions used for hair dyeing and the yield was dependent upon the molar ratio of 2,5-diaminotoluene to 2,4-diaminoanisole.
- 公益社団法人日本薬学会の論文
著者
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Matsuki Yasuhiko
Hatano Research Institute Food And Drug Safety Center:pharmaceutical Institute Tohoku University
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Matsuki Yasuhiko
Hatano Research Institute Food And Drug Safety Center
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Inoue Yasuyuki
Hatano Research Institute Food And Drug Safety Center
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Nambara Toshio
Pharmaceutical Institute Tohoku University
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FUKUHARA KATSUHARU
Hatano Research Institute, Food and Drug Safety Center
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YUI TOHRU
Hatano Research Institute, Food and Drug Safety Center
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Yui Tohru
Hatano Research Institute Food And Drug Safety Center
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Fukuhara Katsuharu
Hatano Research Institute Food & Drug Safety Center
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Fukuhara Katsuharu
Hatano Research Institute Food And Drug Safety Center
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