ANTIINFLAMMATORY PRINCIPLES OF ACONITUM ROOTS
スポンサーリンク
概要
- 論文の詳細を見る
The methanol extracts of Aconitum roots have shown inhibition of increased vascular permeability induced by acetic acid and of hind paw edema produced by carrageenin in mice. The extract of A. carmichaeli has been fractionated, monitored by the capillary permeability test, to yield the aconitines as active principles. The aconitines have inhibited the increased vascular permeability induced by acetic acid in mouse peritoneal cavity and that induced by histamine in rat intradermal sites, and the hind paw edema formation induced by carrageenin in rats and mice at low doses. The benzoylaconines have exhibited inhibitory effects on the aforementioned acute inflammations but at the higher doses. The aconitines have reduced the granulation tissue formation of the chorio-allantoic membrane of the chick embryo. On the other hand, the Aconitum alkaloids have elicited no effects on the ultraviolet erythema formation in guinea pigs at lower doses than the lethal ones and failed to show positive responses on the vascular permeability in the granuloma pouch and on adjuvant arthritis in rats at the doses employed.
- 公益社団法人日本薬学会の論文
著者
-
YAMADA Yoko
Pharmaceutical Research Laboratory, Kirin Brewery Co. Ltd.
-
HIKINO HIROSHI
Pharmaceutical Institute, Tohoku University
-
Ohizumi Yasushi
Pharmaceutical Institute Tohoku University
-
Takata Hiroshi
Pharmaceutical Institute Tohoku University
-
KONNO CHOHACHI
Pharmaceutical Institute, Tohoku University
-
YAMADA CHIZUKO
Pharmaceutical Institute, Tohoku University
-
SUGIO KAZUO
Pharmaceutical Institute, Tohoku University
-
FUJIMURA HAJIME
Gifu University School of Medicine
-
Hikino Hiroshi
Pharmaceutical Department Faculty Of Medicine Tohoku University
-
Sugio Kazuo
Pharmaceutical Institute Tohoku University
-
Konno Chohachi
Pharmaceutical Institute Tohoku University
-
Yamada Chizuko
Pharmaceutical Institute Tohoku University
-
Yamada Yoko
Pharmaceutical Institute Tohoku University
関連論文
- Molecular Cloning of Delta-4, a New Mouse and Human Notch Ligand
- STRUCTURES AND ACTIVITIES OF TANNINS IN CRUDE DRUGS (3)
- ANTIINFLAMMATORY PRINCIPLES OF ACONITUM ROOTS
- BIOLOGICALLY ACTIVE PRINCIPLES OF CRUDE DRUGS. PHARMACOLOGICAL EVALUATION OF CHOLAGOGUE SUBSTANCES IN CLOVE AND ITS PROPERTIES
- BIOLOGICALLY ACTIVE PRINCIPLES OF CRUDE DRUGS. II. ANTI-ALLERGIC PRINCIPLES IN "SHOSEIRYU-TO" ANTI-INFLAMMATORY PROPERTIES OF PAEONIFLORIN AND ITS DERIVATIVES
- ANALGESIC PRINCIPLES OF ACONITUM ROOTS
- LIVER-PROTECTIVE ACTIONS OF DESOXYPODOPHYLLOTOXIN AND ITS ANALOGS
- B-6-1 Structures of _α-Kessyl Alcohol and Kessyl Glycol(Terpenoids)
- Application of Carbon Tetrachloride-Induced Liver Lesion in Mice for Screening of Liver Protective Crude Drugs
- Antihepatotoxic Principles of Swertia japonica Herbs
- Assay Method for Antihepatotoxic Activity Using Ionophore A23187-Induced Cytotoxicity in Primary Cultured Hepatocytes
- Anticomplementary Activity of Lignan-Analogs of Arctium lappa Achenes
- Antihepatotoxic Principles of Aeginetia indica Herbs
- Antihepatotoxic Principles of Salvia plebeia Herbs
- Effect of Mesaconitine on Adenylate Cyclase
- Structure of mugineic acid, a new amino acid possessing an iron-chelating activity from roots washings of water-cultured Hordeum vulgare L.
- Molecular Cloning of Delta-4, a New Mouse and Human Notch Ligand.
- Isolation and Hypoglycemic Activity of Panaxans F, G and H, Glycans of Panax ginseng Roots