LIVER-PROTECTIVE ACTIONS OF DESOXYPODOPHYLLOTOXIN AND ITS ANALOGS
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概要
- 論文の詳細を見る
Effects on CCl_4-induced liver lesion in mice and on D-galactosamine-induced liver lesion in rats of desoxypodophyllotoxin (1) and its analogs, podophyllotoxin (2), podophyllotoxon (3), β-peltatin (4), α-peltatin (5), 4'-demethylpodophyllotoxin (6) and picropodophyllin (7), were investigated. 1 and 7 in CCl_4-induced liver lesion and 1,4,5,and 6 in D-galactosamine-induced liver lesion have shown marked protective actions. These results suggest that these analogs have liver-protective actions in general and the substituents at C-4 in ring C, C-5 in ring B and C-4' in ring E, and the configuration at C-2 in ring C are important for the revelation of the activity.
- 公益社団法人日本薬学会の論文
著者
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HIKINO HIROSHI
Pharmaceutical Institute, Tohoku University
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KISO YOSHINOBU
Pharmaceutical Institute, Tohoku University
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KONNO CHOHACHI
Pharmaceutical Institute, Tohoku University
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Yagi Yukiko
College Of Medical Sciences Tohoku University
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Hikino Hiroshi
Pharmaceutical Institute Tohoku University
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Hikino Hiroshi
Pharmaceutical Department Faculty Of Medicine Tohoku University
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Konno Chohachi
Pharmaceutical Institute Tohoku University
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HASHIMOTO ICHIO
College of Medical Sciences, Tohoku University
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Kiso Yoshinobu
Pharmaceutical Institute Tohoku University
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Hashimoto Ichio
College Of Medical Sciences Tohoku University
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