ANALGESIC PRINCIPLES OF ACONITUM ROOTS
スポンサーリンク
概要
- 論文の詳細を見る
The extract of an Oriental medicine "bushi", Aconitum japonicum roots (raw), was fractionated monitored by the analgesic activity in the tail pressure test, leading to the isolation of a mixture of the aconitines but no other constituents as the active principles. The aconitines have been compared in a variety of animal tests for analgesic activity. As the results, the alkaloids have proved in the tail pressure method and the acetic acid-induced writhing method to show analgesic activity in decreasing order : mesaconitine > aconitine > hypaconitine, though they exhibited no significant activity in the hot plate method. Heating of the raw Aconitum roots at 100°, which is one of the processing procedures of the crude drug, has brought about a rapid decrease of the analgesic activity with concomitant decrease of the content of the aconitines, demonstrating that the benzoylaconines produced by hydrolysis of the aconitines showed little or no analgesic activity. Assay of the benzoylaconines has revealed a weak analgesic activity in the acetic acid-induced writhing test. On the basis of the present results, it is predicted that the clinical effectiveness of the crude drug is due to the aconitines (especially mesaconitine) and partly to the benzoylaconines.
- 公益社団法人日本薬学会の論文
著者
-
Ohizumi Yasushi
Pharmaceutical Institute Tohoku University
-
KONNO CHOHACHI
Pharmaceutical Institute, Tohoku University
-
YAMADA CHIZUKO
Pharmaceutical Institute, Tohoku University
-
Konno Chohachi
Pharmaceutical Institute Tohoku University
-
Yamada Chizuko
Pharmaceutical Institute Tohoku University
-
HIKINO HIROSHI
Parmaceutical Institute, Tohoku University
-
ITO TOMOKO
Parmaceutical Institute, Tohoku University
-
YAMADA CHIZUKO
Parmaceutical Institute, Tohoku University
-
SATO HIROSHI
Parmaceutical Institute, Tohoku University
-
KONNO CHOHACHI
Parmaceutical Institute, Tohoku University
-
OHIZUMI YASUSHI
Parmaceutical Institute, Tohoku University
-
Ito Tomoko
Parmaceutical Institute Tohoku University
関連論文
- ANTIINFLAMMATORY PRINCIPLES OF ACONITUM ROOTS
- ANALGESIC PRINCIPLES OF ACONITUM ROOTS
- LIVER-PROTECTIVE ACTIONS OF DESOXYPODOPHYLLOTOXIN AND ITS ANALOGS
- Application of Carbon Tetrachloride-Induced Liver Lesion in Mice for Screening of Liver Protective Crude Drugs
- Isolation and Hypoglycemic Activity of Panaxans F, G and H, Glycans of Panax ginseng Roots