Molecular Cloning of Delta-4, a New Mouse and Human Notch Ligand.
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概要
- 論文の詳細を見る
Complementary DNAs encoding a previously unidentified mouse Notch ligand and its human ortholog were isolated. The new Notch ligand contains a signal sequence, a DSL domain, eight epidermal growth factor-like repeats, a transmembrane domain, and an intracellular region, all of which are characteristics of members of the Delta protein family. The new protein was therefore designated Delta-4. Several previously unidentified sequences in both the extracellular and intracellular regions were shown to be conserved among vertebrate Delta proteins. The tissue distribution of Delta-4 mRNA resembles that previously described for Notch-4 (Int-3) transcripts. However, in situ hybridization with mouse lung revealed that Delta-4 mRNA is abundant in squamous alveolar cells that neighbor endothelial cells; Notch-4 expression is largely restricted to the latter cell type. Soluble forms of the extracellular portion of Delta-4 inhibit the apparent proliferation of human aortic endothelial cells, but not human pulmonary arterial endothelial cells.
- 社団法人 日本生化学会の論文
著者
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Nagao Kenji
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Nishikawa Mitsuo
Pharmaceutical Research Laboratories Pharmaceutical Division Kirin Brewery Co.
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Miyatani Seiji
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Osawa Masatake
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Yoneya Takashi
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Yamamoto Terumi
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Tahara Tomoyuki
Pharmaceutical Research Laboratory Kirin Brewery Co. Ltd.
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Yamada Yoko
Pharmaceutical Institute Tohoku University
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