Some Physicochemical Properties of 2-Methyl-2-nitrosopropane, Phenyl N-tert-Butyl Nitrone, 5,5-Dimethylpyrroline-N-oxide, and 2,5,5-Trimethylpyrroline-N-oxide and the Feasibility of Their Use as Spin Traps in Aqueous Solution
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概要
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The chemical and photochemical stabilities of 2-methyl-2-nitrosopropane (NtB), phenyl N-tert-butyl nitrone (PBN), 5,5-dimethylpyrroline-N-oxide (DMPO), and 2,5,5-trimethylpyrroline-N-oxide (TMPO) in aqueous solutions were examined and the feasibility of their use as spin traps was evaluated. NtB has a poor solubility in water. The dissociation of dimeric NtB to its active monomeric form is slow and is accompanied by complicated decomposition reactions even in the dark. PBN is subject to hydrolysis in strongly acidic solutions, the rate constant being 90 M^<-1> hr^<-1>. DMPO and TMPO were found to be stable to hydrolysis and fairly inert to photolysis. These results, together with other findings, led us to conclude that DMPO may be the first choice and PBN the second as a spin trap to be used in aqueous solutions.
- 公益社団法人日本薬学会の論文
- 1981-01-25
著者
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桐野 豊
Faculty Of Pharmaceutical Sciences Kyushu University:faculty Of Pharmaceutical Sciences The Universi
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管 孝男
Faculty of Pharmaceutical Sciences, University of Tokyo
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管 孝男
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)faculty Of Pharmaceutical Sc
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管 孝男
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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大熊 高明
Faculty of Pharmaceutical Sciences, The University of Tokyo
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大熊 高明
Faculty Of Pharmaceutical Sciences The University Of Tokyo
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