Methylation of Quinones by Methylcobalt Complexes in the Presence of Palladium Salt

概要

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Methylation of 1,4-quinones by methylcobalt complexes has been studied in the presence or absence of some metal salts. Methylcobaloximes were found to afford monomethylated quinones though the yield was very small in the absence of metal salts. The transmethylation was, however, remarkably promoted in the presence of transition metal salt such as Pd (II) and reached nearly 70% at the highest. Methylcobalamins were also found to methylate 1,4-quinones to a slight extent but no promoting effect was recognized with Pd (II) probably due to complexing side reactions. Nevertheless, the observations may indicate that methylcobalt complexes act as methylating reagents not only for mercuric salts but also for organic compound such as 1,4-quinones. Reaction mechanisms are briefly discussed.
社団法人日本薬学会の論文
1975-05-25