Chiral Syntheses of Dihydroxyamino Acid Moieties of AI-77-B and Calyculins from D-Glucosamine
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概要
- 論文の詳細を見る
Manipulation of cis (4S, 5S)-4,5-disubstituted 2-oxazolidinones (4,5), derived easily from D-glucosamine (1) as a chiral pool, including degradation of the C6-carbon and/or one-carbon homologation at the C1-position allowed chiral syntheses of (2S, 3S)-dihydroxy-(4S)-amino acid moieties (6-8), which are important structural components of a gastroprotective substance, AI-77-B, and a group of antitumor substances, calyculins.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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正木 幸雄
Gifu Pharmaceutical University
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MASAKI Yukio
Gifu Pharmaceutical University
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正木 幸雄
岐阜薬科大学
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MIZUNO Kazuhiro
Gifu Pharmaceutical University
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SHINOZAKI Katsuo
(Present address)Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,
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WAKAMATSU Hideaki
Gifu Pharmaceutical University
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