Remote Asymmetric Induction in Lewis Acid-Catalyzed Diels-Alder Reaction of α, β-Unsaturated Enones Having a Chiral Sulfinyl-Substituted, 5-Membered Aromatic Heterocycle
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概要
- 論文の詳細を見る
Two types of chiral sulfoxides as Diels-Alder dienophiles were synthesized and high levels of diastereoselectivity were observed in cycloadditions. 2-Furyl and 2-thienyl α, β-enones, bearing a chiral sulfinyl group in the heterocycle, served as efficient dienophiles in Diels-Alder reactions, where the catalytic use of aluminium chloride or a lanthanide triflate effected the cycloaddition with cyclopentadiene affording the endo adduct with high diastereoselectivity, ranging from 91% to 98%.
- 公益社団法人日本薬学会の論文
- 1998-07-15
著者
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MASAKI Yukio
Gifu Pharmaceutical University
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Masaki Y
Gifu Pharmaceutical University
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Masuda Tsutomu
Gifu Pharmaceutical University
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ARAI Yoshitsugu
Faculty of Pharmaceutical Sciences, Gifu Pharmaceutical University
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MASUDA Tsutomu
Faculty of Pharmaceutical Sciences, Gifu Pharmaceutical University
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MASAKI Yukio
Faculty of Pharmaceutical Sciences, Gifu Pharmaceutical University
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荒井 謙次
Gifu Pharmaceutical University
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Masaki Y
Gifu Pharmaceutical Univ. Gifu Jpn
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