Synthesis of Chiral Sulfinyl-Substituted 1-Indolyl Enones and Asymmetric Conjugate Addition by an Arylcopper Reagent
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概要
- 論文の詳細を見る
The asymmetric conjugate addition of arylcopper reagents to chiral 1-[2-(p-tolylsulfinyl)]indolyl and 1-[3-(p-tolylsulfinyl)]indolyl enones was examined. With the 2-sulfinyl-indolyl derivatives, the reaction of the arylcopper reagent gave high diastereoselectivities (81-88% de's) to afford the adducts in excellent yields, although the similar addition reaction of the 3-sulfinyl derivatives afforded poor diastereoselectivities.
- 公益社団法人日本薬学会の論文
- 2004-06-01
著者
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MASAKI Yukio
Gifu Pharmaceutical University
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Kasai M
Gifu Pharmaceutical University
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Masaki Y
Gifu Pharmaceutical University
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ARAI Yoshitsugu
Gifu Pharmaceutical University
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Kasai Makoto
Gifu Pharmaceutical University
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