1, 6-Asymmetric Induction during the Conjugate Addition of Arylcopper Reagents to a Chiral Sulfinyl-Substituted Pyrrolyl α, β-Unsaturated Amide
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概要
- 論文の詳細を見る
The asymmetric conjugate addition of arylcopper reagents derived from aryl Grignard reagents and copper(I)iodide to a chiral 1-[2-(p-tolylsulfinyl)]pyrrolyl cinnamide proceeded smoothly to give(3R)-adducts with high diastereoselectivities(≥92% de)in high yields. Conjugate additions either of the cinnamide with the alkyl Grignard reagent-copper(I)iodide combination or of the crotonamide derivative with aryl Grignard reagent-copper(I)iodide gave moderate to good diastereoselectivities. With these sulfinyl pyrrolyl α, β-unsaturated amides, the chiral auxiliary was efficiently recovered without any loss of optical purity after asymmetric conjugate addition.
- 公益社団法人日本薬学会の論文
- 2001-12-01
著者
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MASAKI Yukio
Gifu Pharmaceutical University
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ARAI Yoshitsugu
Gifu Pharmaceutical University
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UEDA Kimio
Gifu Pharmaceutical University
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XIE Jianhua
Gifu Pharmaceutical University
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