高分子π酸触媒の開発
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We reported that dicyanoketene acetals (DCKA), in which gem-dicyano groups of tetracyanoethylene (TCNE) are displaced with alkoxyl groups, function as π-acid catalysts, and that a polymer (poly-DCKA-1) derived by copolymerization of a monomer, in which the alkoxyl group at the ω-position is modified with a styrene moiety, with ethyleneglycol dimethacrylate also shows high level of activities as a π-acid. In this research, the effects of dicyanoketene ethylene acetal (DCKEA), polymers previously developed (poly-DCKA-1 and 2) , new monomers, in which the alkoxyl group at the ω-position is modified with an ethereal moiety, and the corresponding polymers (poly-DCKA-3 and 4) were investigated on catalytic activities. Among the catalysts, the polymer (poly-DCKA-1) had the most efficient activity in monothio-acetalization, cyanation, and Mukaiyama aldol reaction of acetals, two-component and three-component Mannich-type reaction, hydrolysis of acetals and silyl ethers, and two-component and three-component inverse electron demand Aza-Diels-Alder reaction. Remarkably, the polymer catalyst works more efficiently in water than in organic solvents and is recyclable.
- 公益社団法人日本薬学会の論文
- 2006-01-01
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