<総説>メソポーラスシリカを活用する有機合成反応の開発に関する研究

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概要

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• 代表的なメソポーラスシリカとして知られるTi-HMS, MCM-41そしてFSM-16を有機合成反応における反応促進剤として活用することを試みた。ルイス酸サイトを有するTi-HMSが接触還元条件下,選択的に水酸基の脱ベンジル化反応を加速することを見出した。 MCM-41が水酸基の保護基として知られるt-butyldimethylsilyl (TBS)基存在下,triethylsilyl (TES)基を選択的に脱保護できることを見出した。 FSM-16がα-ハイドロキシカルボン酸の酸化的光脱炭酸反応やアリールメチルハライドやアリールメチルアルコールの光酸化反応,スチレン類の酸化開裂反応等幾つかの光反応を促進することを見出した。

• 2003-06-30

著者

• 正木 幸雄

  Gifu Pharmaceutical University

• 正木 幸雄

  岐阜薬科大学:(現)名城大学薬学部薬化学教室

• 児玉 朋寛

  岐阜薬科大学合成薬品製造学教室

• 伊藤 彰近

  岐阜薬科大学合成薬品製造学教室

• 伊藤 彰近

  岐阜薬科大学創薬化学大講座合成薬品製造学研究室

• 伊藤 彰近

  岐阜薬科大学

• 正木 幸雄

  岐阜薬科大学

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