Retinol-Induced Protein Phosphorylation and Emergence of a New Protein Species in Endothelial Cells

概要

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Retinol and vitamin C stimulate the synthesis of plasminogen activator in cultured endothelial cells (Biochem. Biophys. Res. Commun., 130,182,1985). During the course of investigations to clarify the mechanism, the following results were obtained. An 86 kD protein appeared in the cytocol after incubation of the cells with rethinol. Simultaneously, two cytosolic proteins of 78 kD and 100 kD were phosphorylated by endogenous protein kinases. The former was not associated with cyclic adenosine monophosphate-, cyclic guanosine monophosphate- or Ca^<2+>-dependent kinases, while the latter was associated with Ca^<2+>-dependent kinase. These stimulative phenomena are discussed in relation to the synthesis of plasminogen activator induced by retinol.
公益社団法人日本薬学会の論文
1986-04-25