Effects of Vitamin D_3 and Related Compounds on Angiotensin Converting Enzyme Activity of Endothelia Cells and on Release of Plasminogen Activator from Them

概要

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Subculture of bovine endothelial cells with 33 μM vitamin D_3 or 25-(OH)-D_3 for 48 h caused marked morphological change. Angiotensin converting enzyme (ACE) activity of the morphologically changed cells was decreased to approximately one-third and plasminogen activator (PA) activity released from them increased approximately 12-fold as compared to the control cells. Fibrin autography revealed both urokinase-type (53 kDa) and tissue-type (80 kDa) PAs in the culture medium of the cells treated with vitamin D_3. Neither 1,25-(OH)_2-D_3 nor 24,25-(OH)_2-D_3 had any effect on PA activity released from the cells, while ACE activity of the cells was decreased by the treatment with these dihydroxylated vitamins. Provitamin D_3 or cholesterol had no effect on Pa or ACE activities of endothelial cells.
公益社団法人日本薬学会の論文
1988-12-25