Studies on Thiazoline and Thiazolidine Derivatives. XI. Synthesis of 3-N-Alkylthiocarbamoyl-2-alkyliminothiazolidines

概要

論文の詳細を見る
The compounds synthesized through the route (a) and the route (b) as shown in Chart 1 have been assigned by S. Gabriel in the past and by E. Cherbuliez, et al. recently to Type A, N-alkyl-N'-alkyl-N'-(2-thiazolin-2-yl) thiourea (5). We had some doubt in the structure of the above compounds synthesized through the route (a) and (b), so they were hydrolyzed with 15% H_2SO_4 to give Type B, 3-N-alkylthiocarbamoyl-2-oxothiazolidine (6) which was assigned with infrared spectrum (IR), Mass Spectra and nuclear magnetic resonance (NMR) data and confirmed by synthesis of 6 through the route (c). Thus, it was confirmed that the compounds obtained by our synthesis through the route (a) and (b) possessed the Type B structure ; 3-N-alkylthiocarbamoyl-2-alkyliminothiazolidine (4), instead of the Type A structure. The data for ultraviolet spectrum (UV), IR, MS and NMR are shown in Table I, II and III.
公益社団法人日本薬学会の論文
1975-09-25