<原報>N, N-Dimethyl-N'-(4-phenyl-2-thiazolyl) thiourea の誘導体について
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The authors have long been synthesizing various ureido- and thioureido-thiazole derivatives to study systematically on the relationship between the biological activities and their chemical structures, and also studying on the chelate formation of these compounds with metal ions such as Cu, Co, Ni, Pd, etc. Authors have previously reported complex formation between palladium ion and various thioureidothiazole derivatives. Among them, N-methyl-N'-(4-methyl-2-thiazoly)thiourea 1,N, N-dimethyl-N'-(4-phenyl-2-thiazolyl)thiourea 4a have previously been reported for its excellent properties as an organic reagent for spectrophotometric determination of palladium. The structures of the Pd-chelate of compound 1 and also of compound 2 have been identified by mass spectrometry, nuclear magnetic resonance and far infrared spectroscopy. The Pd-chelate complexes of these reagents, however, have certain disadvantages, e.g., only 10∿24nm difference in the maximum absorptions from those of the respective reagents. Thus the excess reagent must be removed prior to photometry. Therefore the author's efforts have been directed towards a new sensitive reagent, the maximum absorption of which appears at sufficiently different wavelength from that reagent itself. First attempts were made to introduce electron-donating groups such as CH_3,Cl and Br or electron-withdrawing e.g., NO_2 in para-posion of the phenyl ring of compound 4a. Following four new compounds 4b-4e, N, N-dimethyl-N'-(4-(p-methyl)phenyl-2-thiazolyl)thiourea 4b, N, N-dimethyl-N'-(4-(p-chloro)phenyl-2-thiazolyl)thiourea 4c, N, N-dimethyl-N'-(4-(p-bromo)phenyl-2-thiazolyl)thiourea 4d, N, N-dimethyl-N'-(4-(p-nitro)phenyl-2-thiazolyl)thiourea 4e were synthesized, which are new compounds according to the author's literature survey. We wish to report synthesis method and spectral data for these compounds.
- 共立薬科大学の論文
- 1980-03-25
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