Studies on Thiazole and Thiazoline Derivatives (XVII) : Methylation of N-Alkyl (or N, N-dialkyl)-N'-(2-thiazolyl) thiourea derivatives
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As shown in Scheme 1 and 2,methylation of title compounds was examined by various kinds of methyl agents. S-methyl derivatives and ring N-methyl derivatives as mono-methyl substituent and ring N, S-dimethyl derivatives as di-methyl substituents were obtained and the structure of these compounds was identified by NMR, Mass, IR, elemental analysis, and the hydrolyzed products of their methyl derivatives. Among them, we found that when S-methyl derivatives, N, N-dimethyl-N'-(4-methyl (or 4,5-dimethyl) thiazole)-S-methylisothiourea, were heated at 155-160°, ring N-methyl derivatives, N, N-dimethyl-N'-(3,4-dimethyl (or 3,4,5-trimethyl) thiazole-2-ylidene) thiourea were obtained. A detailed methyl rearrangement will be reported elsewhere at a later date.
- 共立薬科大学の論文
- 1979-02-25
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