Aliphatic Dehydroxylation of Octopamine in the Rat and Rabbit
スポンサーリンク
概要
- 論文の詳細を見る
The metabolic fate of octopamine has been investigated in the rat and rabbit, using octopamine-2-^3H. Urinary metabolites after oral administration were separated and identified by direct comparison with the authentic samples. The principal metabolite of the drug in both animals was the aliphatic dehydroxylated compound, p-hydroxyphenylacetic acid. Pretreatment with antibiotics (streptomycin and penicillin G potassium) did not cause to change the metabolic pattern of octopamine, suggesting that gut flora did not participate in the aliphatic dehydroxylation of octopamine.
- 社団法人日本薬学会の論文
- 1975-08-25
著者
-
浜田 昭
School of Pharmaceutical Sciences, Showa University
-
黒岩 幸雄
Department Of Biochemical Toxicology School Of Pharmaceutical Sciences Showa University
-
本間 喜久子
School of Pharmaceutical Sciences, Showa University
-
黒岩 幸雄
School of Pharmaceutical Sciences, Showa University
-
浜田 昭
School Of Pharmaceutical Sciences Showa University
-
本間 喜久子
School Of Pharmaceutical Sciences Showa University
関連論文
- A Facile O-Glycosidation using Stannic Chloride
- The Polysaccharide from Lampteromyces Japonicus
- o-Hexyloxybenzamide の生体内運命について
- Effect of Phenobarbital and 3-Methylcholanthrene on Decrease in pH in Liver induced by 3'-Methyl-4-dimethylaminoazobenzene, of Partial Hepatectomy and Hepatotoxic Agents
- Effect of Citric Acid on 3'-Methyl-4-dimethylaminoazobenzene Induced Decrease in Rat Liver pH
- Reduced Nicotinamide Adenine Dinucleotide-dependent O-Deethylation of p-Nitrophenetole with Rabbit Liver Microsomes. II. Involvement of Cytochrome b_5
- Aliphatic Dehydroxylation of Octopamine in the Rat and Rabbit
- Studies on the Metabolic N-Demethylation. II. Barbiturates Induced Acceleration of N-Methylbarbiturates Metabolism.
- Studies on the Metabolic N-Demethylation. I. The Metabolic Fate of Hexobarbital by Rabbit Liver Slice.
- Metabolism of Drugs. XXI. Isolation and Detection of Hydroxyl Derivatives from the Urine of Rabbits receiving Ethylhexabital (EHB, 5-Cyclohexenyl-5-ethylbarbituric Acid) and Normethylhexabital (Nor-MHB, 5-Cyclohexenyl-5-methylbarbituric Acid).
- Metabolism of Drugs. XII. The Effect of β-Diethylaminoethyl Diphenylpropylacetate Hydrochloride (SKF 525-A) on the Metabolism of Ethylhexabital.
- 2-或いは4-ピリジンアルデヒドの簡易合成法
- Enzyme Immunoassay for Cinobufagin
- Isolation and Preliminary Characterization of Two Glycophorins from Rabbit Erythrocyte Membranes
- モデル化合物を用いたトリハロメタン生成反応機構の解析(パネルディスカッション トリハロメタンの生成機構をめぐって)(第8回環境汚染物質とそのトキシコロジーシンポジウム)
- 赤血球膜蛋白の分子特性 (赤血球膜の分子構築)
- Studies on Glycosylation. III. A Novel, Stereospecific Synthesis of 1-O-Acyl- and 1-Aryl-β-D-glucopyranose Tetraacetates via the 1,2-t-Butyl-orthoacetate
- Studies on Glycosylation. II. A S-Glycosylation by Use of Stannic Chloride
- Differential Induction of Hepatic and Renal Microsomal Cytochrome P450 by N-Phenylalkylimidazoles in Rats
- 赤血球膜グリコホリンの構造多様性
- 水中の低沸点有機ハロゲン化合物の微量定量法
- Fungal Polysaccharides. II. Chemical Structure of the Polysaccharide from Lampteromyces japonicus
- ガスクロマトグラフィーによる局所麻酔剤の分析
- Regio-Related Differential Induction of Hepatic Microsomal Heme Oxygenase and Cytochrome P450 by Substituted Imidazole and Pyridine Compounds in Rats
- 30p-BF-7 ヒト赤血球膜の高周波誘電緩和スペクトロスコピー(生体物理)