Reaction of Secondary and Tertiary Amines with Nitric Oxide in the Presence of Oxygen

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概要

• 論文の詳細を見る

• In order to clarify the role of oxygen in the reaction of amines with nitric oxide, secondary amines were allowed to react with nitric oxide in the presence of oxygen. Although N-nitrosamines were obtained as the main products in every case, the yields depended on the substituents and reaction solvents. Detailed investigation revealed that the rection proceeded by at least two pathways : one involving oxygen as a catalyst, and the other consuming the stoichiometric amount of oxygen. Both paths afforded the same nitroso adducts. It was suggested that a third path, a catalytic process via Drago's salts was also possible. The same reaction was applied to a tertiary amine, and it was found that the oxygen was consumed stoichiometrically in this case.

• 公益社団法人日本薬学会の論文
• 1999-06-15

著者

• 伊藤 喬

  昭和大学薬学部

• 伊藤 喬

  昭和大学薬学部薬化学教室

• Itoh T

  Graduate School Of Pharmaceutical Sciences Osaka University

• Itoh Takuya

  Graduate School Of Pharmaceutical Sciences Osaka University

• Itoh Tatsuya

  Faculty Of Pharmaceutical Sciences Hokuriku University

• Nagata K

  School Of Pharmaceutical Sciences Showa University

• Miyazaki Michiko

  School of Pharmaceutical Sciences, Showa University

• Nagata Kazuhiro

  School of Pharmaceutical Sciences, Showa University

• Itoh Takashi

  School of Pharmaceutical Sciences, Showa University

• Ohsawa Akio

  School of Pharmaceutical Sciences, Showa University

• MATSUYA Yuji

  School of Pharmaceutical Sciences, Showa University

• MAETA Hiromi

  School of Pharmaceutical Sciences, Showa University

• Miyazaki Makoto

  Department Of Pharmaceutics Osaka University Of Pharmaceutical Sciences

• Ohsawa A

  School Of Pharmaceutical Sciences Showa University

• Ohsawa Akio

  School Of Pharmaceutical Sciences Showa University

• Maeta Hiromi

  School Of Pharmaceutical Sciences Showa University

• Miyazaki M

  Department Of Pharmaceutics Osaka University Of Pharmaceutical Sciences

• 永田 和弘

  School Of Pharmaceutical Sciences Showa University

• Nagata Kazuhiro

  School Of Pharmaceutical Sciences Showa University

• Itoh Takashi

  School Of Pharmaceutical Sciences Showa University

• Nagata Kazuhiro

  School of Engineering, Tokyo Institute of Technology

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