骨創腔に対するリン酸カルシウム系セラミックスの応用に関する基礎的な知見

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The recent development of biomaterials, especially of ceramics including alumina has been remarkable. The present study was performed in order to investigate histopathologically the healing process of the bone defects to calcium phosphate ceramics (Hydroxyapatite : HAP granules, Tricalcium phosphte : TCP granules) which were implanted into artificially created bone defects in domestic rabbits. The results were as follows : 1. At one week after implantation in bone defects, HAP and TCP granules could be observed in the granulation tissues. There was slight inflammatory cell infiltration. 2. At two week after implantation, HAP and TCP glanules were encapsulated by fibrous connective tissues and formation of osteoblastic cells was seen around them. 3. After three weeks, some of HAP and TCP granules were directly connected with new bone tissues. Neither foregin body reaction nor inflammatory cell infiltration was observed. 4. After four weeks, HAP and TCP granules were embedded in the new bone. Bone repairs had almost completed in control. But in the cases of TCP granule filling, formation of new bone was rather delayed as compared with control. 5. Considering above results, it was suggested that HAP and TCP granules were non-inflammatry and non-stimulative. Further they had good tissue tolerance and osteogenic activity. In these investigations, HAP and TCP granules are considered to be useful as bone graft material to oral surgery.
九州歯科学会の論文

骨創腔に対するリン酸カルシウム系セラミックスの応用に関する基礎的な知見

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