口腔外科入院患者における C 型肝炎ウイルス感染の HCV 抗体と HCV-RNA による検討

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We evaluated the prevalence of HCV infection by serum HCV-RNA and HCV antibody tests among dental hospitalized patients. Subjects included 1923 patients who were hospitalized from January 1994 to December 1996 at the First and Second Divisions of Oral and Maxillofacial Surgery, Kyushu Dental College Hospital, Kitakyushu, Japan. The prevalence of patients with second generation HCV antibody (HCV-2) was 91/1436 (6.3%). HCV antibody by third generation was measured in 57 subjects with HCV-2. Serum HCV-RNA was tested in 62 patients with HCV-2 by reverse transcriptase-polymerase chain reaction. Differences were examined with the unpaired Student's T test where appropriate, and categorical variables were compared using the chi square test or Fisher's exact probability test. Results were considered to be significant when the P value was less than 0.05. In 62 subjects with HCV-2, HCV-RNA was positive in 33 (53.2%), and in 48 patients with HCV-3, HCV-RNA was detected in 30 (62.5%). The prevalence of HCV-RNA was much higher in subjects with HCV-3≩6.7 unit (80.6%) than in those with HCV-3<6.7 unit (4.5%) (P<0.01). Serum alanine transaminase and aspartate transaminase concentrations were significantly higher in subjects with HCV-2 than in those without HCV-2 (P<0.01), while these concentrations did not differ between subjects with and without HCV-RNA. Genotype of HCV was mainly type 2 (70%), and Type 3 (20%) in subjects with HCV-RNA. In conclusion, the prevalence of HCV-RNA in dental patients with HCV antibody was approximately 60%, suggesting that 40% of HCV seropositive patients had no HCV viremia at present. HCV antibody concentration is partly useful for detecting whether the patient has serum HCV-RNA.
九州歯科学会の論文
1998-08-25

口腔外科入院患者における C 型肝炎ウイルス感染の HCV 抗体と HCV-RNA による検討

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