頚椎椎間板変性における骨増殖因子発現の検討

概要

論文の詳細を見る
Several growth factors regulate bone remodeling. Evidence suggests bone morphogenetic protein (BMP) and transforming growth factor-β (TGF-β) promote bone regeneration following fracture and ligamentous ossification in ossification of the posterior longitudinal ligament (OPLL) and ossification of the yellow ligament (OYL). This study was conducted to determine whether BMP and TGF-β are related to intervertebral disc degeneration and cervical spondylosis. Intervertebral disc, posterior longitudinal ligament and posterior vertebral spurs were obtained during anterior discectomy procedures, and examined immunohistochemically. Intervertebral disc cells showed cluster formations in degenerated discs and these cells stained positive for BMP-2/-4 and TGF-β2, which cannot be detected in normal disc. Numerous new blood vessels and mesenchymal cells were observed in migrated discs. Fibrocartilaginous tissue was especially noticeable around vertebral spurs. These tissues stained positive for both BMP-2/-4 and TGF-β2, which may play a role in disc degeneration and may induce vertebral spurs in cervical spondylosis and ectopic ossification of the posterior longitudinal ligament.
日本脊髄外科学会の論文
2002-03-31