Thiamine propyldisulfide同族体の研究 : (VIII)Thiamine tetrahydrofurfuryldisulfide-^<35>Sの吸収および尿中排泄

概要

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In previous papers, the authors studied on the absorption of thiamine propyldisulfide. In this paper, comparison was made between thiamine tetrahydrofurfuryldisulfide and thiamine propyldisulfide labeled with ^<35>S in thiazole ring on the mode of intestinal absorption, the tissue intake, and the urinary metabolites after the oral administration to rat. No difference was found between them in the amount of ^<35>S in urine and various organs and also in the rate of absorption from ligated intestinal canals. As the metabolites of ^<35>S in urine, five main substances, tentatively named as F_1-F_5 besides thiamine were recognized by DEAE-Sephadex fractionation. Among them, F_3-F_5 were considered similar to X-substances, which we have previously reported as the urinary metabolites of thiamine and thiamine propyldisulfide.
日本ビタミン学会の論文
1965-10-25