O-Benzoylthiamine disulfideの研究 : (III)放射性O-Benzoylthiamine disulfideの吸収機構

概要

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The results of experiments on the absorption of benzoylthiamine disulfide (BTDS) labeled in thiazole ring S were reported. The urinary excretion of ^<35>S after intraperitoneal injection of BTDS (990μg as thiamine-HCl) was 42% of the administered doses in 48 hours. BTDS, O-benzoylthiamine and thiamine were found in ligated intestinal cannal and wall, respectively 5 minutes after introducing 500μg of BTDS-^<35>S. In liver homogenate, O-benzoylthiamine and thiamine were recovered 5 minutes after addition of 50μg BTDS-^<35>S. O-benzoylthiamine was found in urine as one of the radiometabolites. Therefore, at the time of absorption from intestinal cannal, reduction of -S-S- of BTDS (formation of O-benzoylthiamine) was thought to be the first step. O-benzoylthiamine may be enzymatically converted to thiamine in the liver. Formation of thiamine diphosphate-^<35>S in the liver after intravenous injection of BTDS-^<35>S (500μg) were 20-30μg, the amounts of thiamine pyrophosphate-^<35>S, thiamine monophosphete-^<35>S, and thiamine-^<35>S were 1-2μg, respectively.
日本ビタミン学会の論文
1966-04-25