放線菌の生産する抗菌性物質に關する研究 (第3報) : Stereomyces vinaceus の抗菌性物質のシステインによる影響

概要

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Although the antibiotic substance of St. vinaceus if effective against some gram-negative bacteria, it is difficult to know whether it is streoptomycin or streoptothricin by bacterial spectrum only. According to the review by Denkeluater etal. and Waksman, streptomycin is inactivated by cystein, but streptothricin is not. Further more Waksman has reported that by agar streak method the activity of streptomycin in the presence of cystein was inactivated seriously against E. coli, but accelerarted against B. subtilis. 1. In order to determine whether the antibiotic substance produced from St. vinaceus belongs to streptomycin or streptothricin, the effects of cystein were tested against E. coli, B. subtilis and Staphylococcus aurous (Terajima) by bouillon dilution and bouillon agar streak method. 2. The activity of antibiotic substance against E. coli and S. aureus was retarded remarkably by the presence of 0.1% cystein and the action against E. coli is reduced to 1/15〜1/20. 3. On the contrary, the activity of this substance against B. subtilis is accelerated, but is not so distinct as in the case of E. coli. 4. From these results, the effects of cystem against the antibiotic substance produced St. vinaceus seem to be similar to streptomycin.
公益社団法人日本生物工学会の論文
1949-08-15