微生物の生産する抗菌性物質 (第7報) 放線菌11号菌の生産する抗生物質 (其の1)

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Strain No. 11 resembles the S.eurocidicus 549-AI in the morphological and cultural characteristics and produces two kinds of antifungal substance (eurocidin, FRC group) and two antibacterial substances (11A, 11B) simultaneously in a culture. Among these antibiotics, the antibacterial substances are dealt in the present paper.The sobstance 11A inhibits the growth of GRAM-positive and GRAM-negative bacteria, but the substance 11B is active only against the GRAM-positive species.The substance 11A separated from the culture solution was purified by sublimation. Judging from the sublimating point, elemental analysis and infrared absorption spectrum, the substance 11A is idential with azomycin. The substance 11B could not be obtained in crystalline form, but as this antibiotic had shown the ultraviolet absorption maxima at 223 mμ and 320 mμ, it would probably be identical with methymycin which belongs to the carbomycin-erythromycin group.
社団法人日本生物工学会の論文
1957-05-15