肝障害にたいするピリドキサールリン酸の効果 : (I)慢性四塩化炭素障害による脂肪肝および肝線維化にたいする影響

概要

論文の詳細を見る
Producing chronic liver damage by intraperitoneal injection of 0.8 g/kg/week of CCl_4 to mature rats of Wistar strain, we observed the influences of pyridoxal phosphate (PAL-P) (5 mg/kg/day), administered with the diet. Increase of neutral lipid in liver (fatty degeneration), rise of liver cholesterol ester ratio and decrease of iodine number of fatty acid in each lipid fraction in liver were observed in the control group. All these changes were found remarkably reduced in PAL-P treated group. Decrease of liver protein and fall of paraphenylene diamine oxidase (copper-protein enzyme) activity were also reduced in PAL-P treated group. Histologically, vacuolar degeneration of liver cells, proliferation of collagenous fibres and decreases of PAS-positive substances and pyroninophile substance (ribonucleic acid) were observed markedly improved in PAL-P treated group. All these effects are considered to be due to pyridoxal, because PAL-P is thought to be absorbed after the dephosphorylation in intestine.
日本ビタミン学会の論文
1964-02-25