医用磁性ナノビーズのポストゲノム解析時代における新展開

概要

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The end of the genomic-era has resulted in new scientific challenges in the field of biomedical research. In particular, there are increasing demands for the development of high performance, nanometer sized, polymer-coated magnetic beads for use as carriers for high throughput bio-screening (HTBS). The use of HTBS technology will enable not only the collection of bio-receptors and affinity-coupled chemicals (candidates for new drugs) but also the elucidation of mechanisms causing the side effects of drugs. This research will facilitate the development of novel drugs and tailored medicine based on personal genetic information as well as global commercial enterprises. We first present the pertinent background for a fundamental understanding of HTBS, DNA diagnoses, and immunoassays, whose performance can be greatly improved by substituting conventional sub-micron or larger magnetic beads with nanometer sized beads. We then describe our invention that permits polymer coatings or physiologically active molecules to cover/attach to ferrite surfaces by strong chemical bonds during ferrite bead synthesis. As an extension of our technology, we propose the use of high performance magnetic carriers for MRI contrast enhancement, hyperthermia, and drug delivery, which have anti-cancer antibodies immobilized onto their surfaces in order to selectively couple carriers to cancer cells.
社団法人日本磁気学会の論文
2004-07-01