〈Reviews〉Physiological Science of Leptin : Recent Findings
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概要
- 論文の詳細を見る
KOMABAYASHI, T., SUDA, K. and IZAWA, T., Physiological Science of Leptin : Recent Findings. Abv. Exerc. Sports Physiol., Vol.9, No.3 pp.77-90, 2003. Obesity is a widespread disease and a major risk factor fot type 2 diabetic mellitus, atherosclerosis and hypertension. It is known that adipose tissue is a major secretory and endorine organ imvolved in a range of functions beyond simple fat storage. The discovery of the obese (ob) gene has provided new insights into the study of obesity. Leptin, the product of the adipose-specific ob gene, regulates food intake and energy expenditure to maintain stable body weight, through central and peripheral mechanisms. In particular, central effects occur through the activation of the lohg-form of leptin receptors in the hypothalamus, specifically in the arcuate nucleus. The ob gene expression and leptin secretion are modulated through sympathetic activity and several hormones, including insulin and glucocorticoids, in adipose tissue. Furthermore, the physiological factors that influence leptin secretion include gender, adiposity, ohysical exercise, feeding, and caloric restriction. Circulating leptin levels are positively related to body fat content, percent body fat and BMI, but not age. Leptin is linked to a variety of reproductive processes and the levels vary during pregnancy. The effects of exercise and diabetes mellitus on ob mRNA expression and circulating leptin levels are also discussed.
- 日本運動生理学会の論文
著者
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Izawa Tetsuya
Department Of Exercise And Sport Science Graduate School Of Science Tokyo Metropolitan University
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Suda Kazuhiro
Department Of Human System Science Graduate School Of Decision Science And Technology Tokyo Institut
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Suda Kazuhiro
Department Of Human System Science Graduate School Of Decision Science And Technology Tokyo Institut
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Komabayashi Takao
Laboratory For Nutritional Science Musashigaoka College
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Komabayashi Takao
Dept. Of Physiol. Tokyo Coll. Of Pharma.
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KOMABAYASHI TAKAO
東京薬科大学第2薬理学教室
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