ANP Release Response to Prolonged Swimming in DOCA-salt Hypertensive Rats
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概要
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Plasma ANP concentration increases during exercise. ANP(atrial natriuretic peptide) dilates blood vessels and increases natriuresis, and eventually reduces blood pressure. Although exercise is recommended for moderate hypertensive patients, change of blood concentration of this peptide in hypertensive animals during exercise is not known in detail. We produced DOCA (Deoxycorticosterone acetate) -salt hypertensive model rats and used them as the hypertensive group. Both systolic and diastolic blood pressures were elevated in the hypertensive group compared to the normotensive group at 5, 7 and 9 weeks of age. We measured plasma ANP concentration and ANP content of both left and right atria and ventricles of the hypertensive rats and normotensive rats, at rest and after three hours of swimming. Plasma ANP concentration of the hypertensive group (42.7±8.9 pg/ml) was significantly higher than the normotensive group (10.7±3.1 pg/ml). Exercise significantly increased plasma ANP concentration to 22.8±4.7 pg/ml in the normotensive group but significantly decreased to 11.9±2.0 pg/ml in the hypertensive group. ANP content in the right atria was siginificantly lower after exercise (234.7±61.9 μg/g) than at rest (516.8±105.5 μg/g), and ANP content in the right ventricles were significantly higher after exercise (2.4±0.3 μg/g) than at rest (0.8±0.2 μg/g) in the normotensive group. There was no statistically significant difference of ANP content in the myocardium between the two conditions (after exercise and at rest) in the hypertensive group. These results suggest that the ANP release reaction to exercise is different in the hypertensive group from the normotensive group.
- 2012-11-00
著者
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Suda Kazuhiro
Department Of Human System Science Graduate School Of Decision Science And Technology Tokyo Institut
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KOMABAYASHI Takao
Department of Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology
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TAKARA Atsushi
Department of Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology
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SUDA Kazuhiro
Department of Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology
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