Effect of Prolonged Exercise on BNP Content in the Myocardium from DOCA-salt Hypertensive Rats
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概要
- 論文の詳細を見る
To investigate the effect of exercise on plasma BNP and BNP content in the myocardium in hypertensive animals, we produced DOCA (deoxycorticosteron acetate) -salt hypertensive model rats, and examined plasma BNP concentration and BNP content in the myocardium at rest, and after 3 hours of swimming. Mean blood pressure of the hypertensive group was 131.3±2.3 mmHg, which was significantly higher than the normotensive group (97.9 mmHg) at 9 weeks old. Plasma BNP concentration was also significantly higher in the hypertensive group than the normotensive group (0.38±0.09 ng/ml and 0.15±0.02 ng/ml, respectively) in accordance with previous studies. Volume overload, wall stretch, and hemodynamics might cause BNP secretion. BNP content changed especially in the right ventricle. Exercise-induced wall stretch in the right ventricle might cause BNP synthesis in the myocardium.
- 日本運動生理学会の論文
- 2013-07-00
著者
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Suda Kazuhiro
Department Of Human System Science Graduate School Of Decision Science And Technology Tokyo Institut
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TAKARA Atsushi
Department of Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology
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