Phage-inactivating Effect of Iron(II) : Ascorbate Complex

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概要

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• The effect of iron (II)-ascorbate complex on various phages was investigated. At 10^<-6> M, the complex inactivated all nine phages examined. The mechanism of the inactivation was studied with phage J1,the most sensitive to the complex. The addition of H_2O_2 or Cu^<2+> to the reaction mixture increased the inactivation. Bubbling of nitrogen through the reaction mixture and the addition of Fe^<3+>, a reducing agent, a chelating agent, or a radical scavenger prevented inactivation. These findings suggest the involvement of oxygen radicals in the inactivation. The complex had no effects on the SDS-PAGE pattern or amino acid composition of bovine serum albumin, or the structural protein of phage J1. The complex nicked the supercoiled form of pUC18 DNA, giving first single-stranded breaks (the open circular form) and then double-stranded breaks (the linear form). Strands of M13mp8 DNA, λDNA, and J1 DNA were also broken. The breaks could account for the inactivation.

• 社団法人日本農芸化学会の論文
• 1992-05-23

著者

• Murata Akira

  Department Of Cardiology Toyohashi Heart Center

• Kato Fumio

  Department of Microbiology, School of Pharmaceutical Sciences, Toho University

• Kato Fumio

  Dept. Radiat. Biol. & Health Sch. Med. Univ. Of Occup. & Environm. Health

• Kato Fumio

  Department Of Applied Biological Science Faculty Of Agriculture Saga University

• Kato Fumio

  Department Of Applied Biological Science Saga University

• Murata Akira

  Department Of Applied Biological Science Faculty Of Agriculture Saga University

• Murata Akira

  Department Of Mechanical Systems Engineering Tokyo University Of A&t

• Murata A

  Department Of Mechanical Systems Engineering Tokyo University Of Agriculture And Technology

• Kato F

  Department Of Applied Biological Science Faculty Of Agriculture Saga University

• KANDA KOHZO

  Department of Applied Biological Sciences, Faculty of Agriculture, Saga University

• LHO Il-Hwan

  Department of Applied Biological Sciences, Saga University

• MORITA Kohzo

  Department of Applied Biological Sciences, Saga University

• MIYAKE Hiromichi

  Department of Applied Biological Sciences, Saga University

• SAKAMOTO Kohji

  Department of Applied Biological Sciences, Saga University

• Lho Il-hwan

  Department Of Applied Biological Sciences Saga University

• Morita Kohzo

  Department Of Applied Biological Sciences Saga University

• Sakamoto Kohji

  Department Of Applied Biological Sciences Saga University

• Kohzo Kanda

  Department Of Applied Biological Sciences Faculty Of Agriculture Saga University

• Kanda Kohzo

  Department Of Applied Biological Sciences Faculty Of Agriculture Saga University

• Miyake Hiromichi

  Department Of Applied Biological Sciences Saga University

• Kato Fumio

  Department Of Agricultural Chemistry Saga University

• Murata Akira

  Department Of Agricultural Chemistry Saga University

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