Effect of α,α-Dialkyl Amino Acids on the Protease Resistance of Peptides(Organic Chemistry)
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概要
- 論文の詳細を見る
A tryptic [EC 3.4.21.4] digestion assay of 2-aminoisobutyric acid (Aib)-containing peptides was carried out to investigate the effect of α,α-dialkyl amino acid residues on the protease resistance. The introduction of Aib residues to the P1' positions exhibited a 19-fold higher protease resistance than the peptide with Aib residues introduced to the P2 position or the non-Aib peptide. The peptide having Aib residues introduced to the P1' and P2 positions resulted in complete resistance.
- 社団法人日本農芸化学会の論文
- 2003-10-23
著者
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Yamaguchi Hiroshi
Department Of Cardiology Juntendo University
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OSADA Satoshi
Department of Chemistry, Faculty of Science and Engineering, Saga University
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KODAMA Hiroaki
Department of Chemistry, Faculty of Science and Engineering, Saga University
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Kodama H
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Kodama Hiroaki
Dept. Biore. Chem. Fac. Horti. Chiba Univ.
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Kuwahara H
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Kato Fumio
Department of Microbiology, School of Pharmaceutical Sciences, Toho University
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Osada Satoshi
Department Of Chemistry And Applied Chemistry Faculty Of Science And Engineering Saga University
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Kato Fumio
Faculty of Pharmaceutical Sciences, Toho University
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JELOKHANI-NIARAKI Masood
Department of Chemistry, Wilfrid Laurier University
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KONDO Michio
Department of Chemistry, Faculty of Science and Engineering, Saga University
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Kodama H
Saga Univ. Saga Jpn
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Kodama Hiroaki
東京理科大学 薬学部分子病態学
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Kato Fumio
Dept. Radiat. Biol. & Health Sch. Med. Univ. Of Occup. & Environm. Health
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Kato Fumio
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Kato Fumio
Department Of Applied Biological Science Saga University
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Jelokhani‐niaraki M
Department Of Chemistry Wilfrid Laurier University
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Jelokhani-niaraki Masod
Department Of Chemistry Faculty Of Science Wilfrid Laurier University
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Kodama Hiroaki
Department Of Anatomy Ohu University School Of Dentistry
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Kato F
Department Of Applied Biological Science Faculty Of Agriculture Saga University
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Kondo M
Department Of Health And Welfare Nishikyushu University
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Satoshi Osada
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Kato Fumio
Department Of Agricultural Chemistry Saga University
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Kondo Michio
Faculty Of Science And Engineering Saga University
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Kondo Michio
Department Of Chemistry Faculty Of Science And Ehgineering Saga University
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Yamaguchi H
Department Of Chemistry Faculty Of Science And Engineering Saga University
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Yamaguchi Hiroshi
Department Of Anatomic Pathology Graduate School Of Medical Sciences Kyushu University
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Osada Satoshi
Saga Univ. Saga Jpn
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Jelokhani-Niaraki Masood
Department of Chemistry, Faculty of Science, Wilfrid Laurier University
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Jelokhani-Niaraki Masood
Department of Chemistry, Faculty of Science and Engineering, Saga University
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