An Antimutagenic Metabolite, Streptovaricin C, Isolated from Streptomyces sp.
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概要
- 論文の詳細を見る
Streptomyces sp. KM1-30 was isolated from soil as a producer of antimutagens by screening with a modified Ames test. The chemical structure of the antimutagenic metabolite was identified as streptovaricin C, which is known to inhibit DNA dependent RNA polymerase from E. coli and RNA dependent DNA polymerase from RNA tumor viruses, by MS and ^1H-, ^<13>C-NMR analyses. Addition of streptovaricin C to the cultures of UV treated Salmonella typhimurium TA100 or Trp-P-2-treated S. typhimurium TA98 decreased the frequency of mutation without a decrease in viable cell counts. The effect of streptovaricin C to the mutation induced by UV and Trp-P-2 was not desmutagenic, but antimutagenic.
- 公益社団法人日本薬学会の論文
- 1999-01-15
著者
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Ishikawa Tsutomu
Department Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Universit
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Kato Fumio
Department Of Microbiology School Of Pharmaceutical Sciences Toho University
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Tanaka Michiyasu
Department Of Microbiology School Of Pharmaceutical Sciences Toho University
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Kato Fumio
Department Of Agricultural Chemistry Saga University
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OOKA Kazuhiro
Department of Microbiology, School of Pharmaceutical Sciences, Toho University
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Ishikawa Tsutomu
Department Of Medicinal Organic Chemistry School Of Pharmaceutical Sciences Chiba University
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Ooka Kazuhiro
Department Of Microbiology School Of Pharmaceutical Sciences Toho University
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Ishikawa Tsutomu
Department Of Materials Science And Engineering Kyushu University
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ISHIKAWA TSUTOMU
Department of Chemical Engineering, Tokyo Institute of Technology
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