Isolation of Acridone Alkaloids and N-[(4-Monoterpenyloxy)phenylethyl]-Substituted Sulfur-Containing Propanamide Derivatives from Glycosmis parva and Their Anti-herpes Simplex Virus Activity
スポンサーリンク
概要
- 論文の詳細を見る
Six acridone alkaloids including a new glycosparvarine (1), three limonoids, and four N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives including two new species, (+)-S-deoxydihydroglyparvin (10) and (+)-S-deoxytetrahydroglyparvin (11), were isolated from the branches and the leaves of Glycosmis parva CRAIB collected in the east of Thailand. Antiviral activity evaluation of isolates against herpes simplex virus (HSV) type 1 and 2 disclosed that two acridone alkaloids, glycosparvarine (1) and glycofolinine (4), showed moderate inhibitory activities with 50% effective concentration (EC50) of 348 μM and 151 μM, respectively; as well, (+)-S-deoxydihydroglyparvin (10) exhibited anti-HSV activity at the lower concentration.
- 公益社団法人 日本薬学会の論文
著者
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KUMAMOTO Takuya
Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba Univers
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ISHIKAWA Tsutomu
Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba Univers
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RUANGRUNGSI Nijsiri
Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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Ishikawa Tsutomu
Department Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Universit
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Lipipun Vimolmas
Department Of Microbiology Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Chansriniyom Chaisak
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalong
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Kumamoto Takuya
Department Of Medicinal Organic Chemistry Graduate School Of Pharmaceutical Sciences Chiba Universit
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Ruangrungsi Nijsiri
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Chulalongkorn University
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Ishikawa Tsutomu
Department Of Materials Science And Engineering Kyushu University
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Ruangrungsi Nijsiri
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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Lipipun Vimolmas
Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University
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Kumamoto Takuya
Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University
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ISHIKAWA TSUTOMU
Department of Chemical Engineering, Tokyo Institute of Technology
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