Sheng-Mai-San is Protective Against Post-Ischemic Myocardial Dysfunction in Rats Through Its Opening of the Mitochondrial KATP Channels

スポンサーリンク

概要

• 論文の詳細を見る

• The present study used isolated rat hearts to investigate whether (1) Sheng-Mei-San (SMS), a traditional Chinese formulation comprising Radix Ginseng, Radix Ophiopogonis and Fructus Schisandrae, is protective against postischemic myocardial dysfunction, and (2) whether the cardioprotective effect of SMS is related to scavenging of hydroxyl radicals and opening the mitochondrial K_<ATP> channels. The excised hearts of male Sprague-Dawley rats were perfused on a Langendorff apparatus with Krebs-Henseleit solution with a gas mixture of 95% O_2 and 5% CO_2. Left ventricular end-diastolic pressure (LVEDP, mmHg), left ventricular developed pressure (LVDP, mmHg), ±dP/dt(mmHg/s) and coronary flow (ml/min) were continuously monitored. All hearts were perfused for a total of 120 min consisting of a 30-min pre-ischemic period followed by a 30-min global ischemia and 60-min reperfusion. Lactate, lactate dehydrogenase (LDH) and 2,5-dihydroxybenzoic acid (2,5-DHBA) concentrations in the effluent were measured during reperfusion. Three days' treatment with SMS (1.67 ml/kg per day) inhibited the rise in LVEDP and improved the post-ischemic LVDP and ±dP/dt significantly better than in the untreated control hearts during reperfusion. SMS increased the coronary flow at baseline, and during reperfusion. Pretreatment with 5-hydroxydecanoic acid (5-HD), a mitochondrial K_<ATP> channel blocker, abolished the inhibition of the rise in LVEDP, the increase in coronary flow and the improvement in LVDP and ±dP/dt induced by SMS. SMS significantly attenuated the concentrations of lactate, LDH and 2,5-DHBA during reperfusion, but the pretreatment with 5-HD restored them; 5-HD alone did not affect the concentrations. SMS improved the post-ischemic myocardial dysfunction through opening the mitochondrial K_<ATP> channels.

• 社団法人日本循環器学会の論文
• 2002-07-20

著者

• MINATOGUCHI Shinya

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• TAKEMURA Genzou

  Second Department of Internal Medicine, Gifu University Graduate School of Medicine

• FUJIWARA Hisayoshi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Arai Masazumi

  Second Department of Internal Medicine, Gifu University School of Medicine

• Uno Yoshihiro

  Department Of Cardiology Gifu University Graduate School Of Medicine

• Akao Seigo

  Department of Oriental Medicine, Gifu University School of Medicine

• WANG Ningyuan

  Second Department of Internal Medicine, Gifu University School of Medicine

• Chen Xue-hai

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Wang Ningyuan

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Uno Yoshihiro

  Second Department of Internal Medicine, Gifu University School of Medicine

• Nishida Yoshio

  Second Department of Internal Medicine, Gifu University School of Medicine

• Hashimoto Kazuaki

  Second Department of Internal Medicine, Gifu University School of Medicine

• 藤原 久義

  岐阜大学 大学院医学研究科東洋医学講座

• Uno Yoshihiro

  The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine

• Fukuda Kazunori

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Xue-Hai Chen

  Second Department of Internal Medicine, Gifu University School of Medicine

• Akao Seigo

  Second Department of Internal Medicine, Gifu University School of Medicine

• Hashimoto Kazuaki

  2nd Department of internal Medicine, Gifu University School of Medicine

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Minatoguchi Shinya

  Second Department Of Internal Medicine Gifu University Graduate School Of Medicine

• Nishida Yoshio

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Akao Seigo

  Department Of Oriental Medicine Gifu University School Of Medicine

• Hashimoto Kazuaki

  2nd Department Of Internal Medicine Gifu University School Of Medicine

• Fujiwara Hisayoshi

  Second Department Of Internal Medicine Faeulty Of Medicine Gifu University

• Takemura Genzou

  Second Dep. Of Internal Medicine Graduate School Of Medicine Gifu Univ.

関連論文

• Transcatheter embolization by autologous blood clot is useful management for small side branch perforation due to percutaneous coronary intervention guide wire
• Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
• Conservative Medication Follow-up for Over 20 Years of a Patient With Ischemic Heart Disease After Diagnosis of Chronic Total Occlusion of the 3 Main Coronary Arteries
• Renoprotective Effect of the Addition of Losartan to Ongoing Treatment with an Angiotensin Converting Enzyme Inhibitor in Type-2 Diabetic Patients with Nephropathy
• Reduction of QTc Dispersion by the Angiotensin II Receptor Blocker Valsartan May Be Related to Its Anti-Oxidative Stress Effect in Patients with Essential Hypertension
• Granulocyte Colony-Stimulating Factor : A Noninvasive Regeneration Therapy for Treating Atherosclerotic Peripheral Artery Disease
• PJ-723 The Anti-Diabetic Drug Voglibose Reduces Myocardial Infarct Size and Improves Left Ventricular Function via Production of Glucagon-like Peptide-1 in Rabbits(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 7
• PE-228 Migritol Improve Myocardial Ischemia in Type 2 Diabetic Patients with Coronary Artery Disease(Nuclear cardiology(04)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-184 The anti-Diabetic Drug Pioglitazone Reduces Myocardial Infarct Size by Stimulating PPARγ, PI3K and Akt in Rabbits Model of Myocardial Infarction(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annu
• Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits
• OJ-254 Erythropoietin Drug Delivery System protects the heart against myocardial infarction through activation of Akt and angiogenesis(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OE-128 Pioglitazone, an Anti-Diabetic Drug, Reduces Myocardial Infarct Size via Stimulating Peroxisome Proliferator Activated Receptor-γ (PPARγ) in Rabbits Model of Myocardial Infarction(Myocardial ischemia/reperfusion, basic/clinical-1, The 71st Annual S
• Water Extract of the Root of Lindera strychnifolia Slows Down the Progression of Diabetic Nephropathy in db/db Mice (Kidney/Renal Circulation 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Hydroxyl Radical Generation by the Combination of Iron and Ascorbic Acid is Greatly Attenuated but Still Significant in Human Grastric Juice
• Apoptotic Cell Loss Following Cell Proliferation in Renal Glomeruli of Otsuka Long-Evans Tokushima Fatty Rats
• OE-311 Miglitol, an Alpha-Glucosidase Inhibitor, Improves Myocardial Ischemia in Diabetic Patients with Coronary Artery Disease(OE53,Nuclear Cardiology (Coronary, Myocardium) 2 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japa
• PJ-114 Erythropoietin Receptor Signaling Mitigates Renal Dysfunction-Associated Heart Failure through Direct Cardioprotective Actions Independent of Erythrogenesis(Heart failure, basic(05)(M),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
• PE-117 Sustained Release of Erythropoietin Using Biodegradable Gelatin Hydrogel Persistently Improves Lower Leg Ischemia without Evoking Polycytemia(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting
• Relation between Various Risk Factors and Tissue Characterization of Atherosclerosis in Coronary Arteries : An Integrated Backscatter Intravascular Ultrasound Study(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting
• Different Effects of Pravastatin and Cerivastatin on the Media of the Carotid Arteries as Assessed by Integrated Backscatter Ultrasound
• FRS-010 The Ubiquitin/Proteasome Pathway Modulates the Mode of Cell Death and Ubiquitin Overexpression Protects Against Oxidative Stress in Adult Rat Cardiomyocytes(Angiogenesis and Regeneration Medicine in Cardiovascular Medicine (M) : FRS3)(Featured Res
• Different Effects of Various Statins on Medial Sclerosis of Carotid Arteries as Assessed by Integrated Backscatter Ultrasound and Histological Meanings
• Volumetric Analysis for Tissue Characterization of Coronary Plaques by Use of Three-Dimensional Integrated Backscatter Intravascular Ultrasound (3D IB-IVUS)
• Development of a New IB-IVUS Color-Coded Mapping System for 2-D Tissue Characterization of Coronary Arterial Plaques and the Clinical Application
• Relation between Various Risk Factors and Tissue Characterization of Atherosclerosis in Coronary Arteries : An Integrated Backscatter Intravascular Ultrasound Study(Intravascular Endoscopy/Intravascular Ultrasound 4 (I), The 69th Annual Scientific Meeting
• Assessment of carotid arterial tissue character after statin therapy using integrated backscatter ultrasound
• Sarpogrelate, a 5-HT_2 Receptor Blocker, may Have a Preconditionieg-Like Effect in Patients With Coronary Artery Disease
• Celiprolol, a Selective β_1-Blocker, Reduces the Infarct Size Through Production of Nitric Oxide in a Rabbit Model of Myocardial Infarction
• Nicorandil Improves Post-Ischemic Myocardial Dysfunction in Association With Opening the Mitochondrial KATP Channels and Decreasing Hydroxyl Radicals in Isolated Rat Hearts
• PJ-440 Ginsenoside Rg1 Reduces Myocardial Infarct Size via Activation of Protein Kinase C and Production of Nitric Oxide in Rabbits(Acute myocardial infarction, basic-4 (IHD) PJ74,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
• PJ-343 Post-infarction Treatment with Ginsenoside Rg1 Improves Cardiac Function and Left Ventricular Remodeling Through Enhancement of Intrinsic G-CSF(Cardiovascular pharmacology, basic/clinical-4 (H) PJ58,Poster Session (Japanese),The 70th Anniversary An
• PE-078 Pravastatin Reduces Myocardial Infarct Size Through Nitric Oxide Production, Protein Kinase C Activation, Mitochondrial KATP Channel Opening and Decreasing Oxyradicals(Cardiovascular pharmacology, basic/clinical-3 (H) PE13,Poster Session (English),
• Cilnidipine, an N+L-Type Dihydropyridine Ca Channel Blocker, Suppresses the Occurrence of Ischemia/Reperfusion Arrhythmia in a Rabbit Model of Myocardial Infarction
• Acarbose, an α-glucosidase Inhibitor, Reduces Myocardial Infarct Size in Rabbits Involving the Opening of Mitochondrial KATP Channels(Diabetes/Obesity 8 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-584 Nicorandil Reduces the Production of Hydroxyl Radicals During Ischemia and Reperfusion Through Opening the Mitochondrial KATP Channels in Rabbit Hearts(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• PJ-377 Healing Process Acceleration May be Important as a Mechanism of Improvement of Cardiac Function and Remodeling by Post-infarct G-CSF Treatment(Apoptosis/Necrosis/Regeneration 1 (M) : PJ63)(Poster Session (Japanese))
• OJ-505 Regeneration-Unrelated Mechanisms Underlying Ameliorating Effect of Bone Marrow Cell Transplantation Therapy in Rabbit Hearts with Cardiomyopathy(Cardiomyopathy, Basic (M) : OJ62)(Oral Presentation (Japanese))
• Tendai-Uyaku Improves Post-Ischemic Left Ventricular Dysfunction through Inhibiting Production of Hydroxy Radicals and Opening the Mitochondrial KATP Channels
• Nicorandil Has a Free Radical Scavenging Effect through Opening the Mitochondrial KATP Channels during Ischemia and Reperfusion in Rabbits
• Miglitol Reduces Myocardial Infarct Size via Scavenging Hydroxyl Radicals, Enhancing Bel-XL Expression and Reducing Bax Expression in Rabbits
• Ameliorating Effect of Autologous Bone Marrow Cell Transplantation in Rabbit Hearts with Cardiomyopathy
• J-SAP Study 1-2: Outcomes of Patients With Stable High-Risk Coronary Artery Disease Receiving Medical-Preceding Therapy in Japan : A Comparison With CABG-Preceding Therapy
• Nuclear Hypertrophy Reflects Increased Biosynthetic Activities in Myocytes of Human Hypertrophic Hearts(Clinical Investigation)
• Caspase-Dependent and Serine Protease-Dependent DNA Fragmentation of Myocytes in the Ischemia-Reperfused Rabbit Heart : These Inhibitors Do Not Reduce Infarct Size
• Evidence of a Cellular Protective Effect by Antecedent Angina Independent of Collateral Flow Recruitment During Coronary Angioplasty in Humans
• OJ-246 Angiotensin II Type 1 Receptor Blockade Inhibits Fas Expression and Apoptosis of Postinfarction Granulation Tissue Cells(Heart failure, basic-2 The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PE-466 G-CSF Improves Cardiac Function of Nonischemic Cardiomyopathy Induced by Doxorubicin(Heart failure, basic-3 (M) PE78,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-447 Hepatocyte Growth Factor Gene Therapy in Doxorubicin-induced Cardiomyopathy(Cardiomyopathy, basic/clinical-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-158 Cationized Gelatin Delivery of a Plasmid Encoding Soluble Fas Mitigates Postinfarction Left Ventricular Remodeling(Acute myocardial infarction, basic-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Dehydroepiandrosterone-sulfate concentration in men from a Japanese longevity district
• PJ-781 Cross-Talk between Nitric Oxide and Hydroxyl Radicals is Involved in the Reduction of Infarct Size By Edaravone(Myocardial ischemia-reperfusion, basic/clinical-6 (IHD) PJ136,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting o
• 3 Comparison of Outcomes of Medical Therapy and PCI as Initial Treatment for Low-risk Stable Angina(Symposium 7 (SY7) (IHD) : Longterm Prognosis of Japanese Patients with Coronary Disease : Medical Therapy, PCI, Surgical Intervention)(Special Program)
• 1 "Treatment for One-vessel Disease : PCI or Medical Therapy? "From the Standpoint of Medical Therapy(Controversy 1 (C1) (IHD) : Management of Single Vessel Disease)(Special Program)
• 4 The Present Status and Problems of Coronary Intervention Clarified by a Nationwide Institutional Investigation(Roundtable Discussion 2 (RT2) (H) : How to Do in a New Paradigm of Japanese Medical Insurance)(Special Program)
• Functional Compartmentalization of ATP is Involved in the Angiotensin II-mediated Closure of Cardiac ATP-sensitive K^+ Channels
• OJ-179 Long Term Effect of Granulocyte Colony-Stimulating Factor as a Novel and Noninvasive Regeneration Therapy Against Atherosclerotic Peripheral Artery Disease(Peripheral Circulation/Vascular Disease 1 (H) : OJ21)(Oral Presentation (Japanese))
• Granulocyte Colony-Stimulating Factor Effectively Improved Blood Flow in Ischemic Lower Limbs in Patients with Arteriosclerosis Obliterans
• OE-204 Total Spasm Provoked by Ergonovine is an Important Prognostic Factor on Cardiovascular Events in Patients with Vasospastic Angina(Coronary circulation, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Jap
• OE-025 Benidipine Significantly Prevented Cardiovascular Events Compared to Diltiazem in Patients With Vasospastic Angina(Cardiovascular pharmacology, basic/clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circ
• PJ-792 The Benefitial Effects of Teaching Cardiac Auscultation by Using a Heart Sound Simulator "Ichiro"(Preventive medicine/Epidemiology/Education-8 (H) PJ139,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circul
• Cardiomyopathy with Prominent Autophagic Degeneration, Accompanied by an Elevated Plasma Brain Natriuretic Peptide Level Despite the Lack of Overt Heart Failure
• In Vivo Quantitative Tissue Characterization of Angiographically Normal Coronary Segment (ANS) Assessed by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)
• Quantitative Tissue Characterization of Coronary Plaques with Progression Assessed by Integrated Backscatter Intravascular Ultrasound (IB-IVUS)
• Vasopressin Inhibits Sarcolemmal ATP-Sensitive K+ Channels via V_1 Receptors Activation in the Guinea Pig Heart
• Sesquiterpene Lactone Suppresses Vascular Smooth Muscle Cell Proliferation and Migration via Inhibition of Cell Cycle Progression(Pharmacognosy)
• Relationship Between Functional Exercise Capacity and Functional Stenosis in Patients With Stable Angina and Intermediate Coronary Stenosis
• Over 10 years clinical outcomes in patients with mitral stenosis with unilateral commissural calcification treated with catheter balloon commissurotomy : Single-center experience
• Outcomes of Patients With Stable Low-Risk Coronary Artery Disease Receiving Medical- and PCI-Preceding Therapies in Japan : J-SAP Study 1-1
• Primary Cardiac Leiomyosarcoma Growing Rapodly and Causing Right Ventricular Outflow Obustruction
• Heart Disease in Friedreich's Ataxia : Observation of a Case for Half a Century
• MODULATION OF NORADRENALINE RELEASE VIA ACTIVATION OF PRESYNAPTIC β-ADRENOCEPTORS IN RABBITS WITH ADRIAMYCIN-INDUCED CARDIOMYOPATHY
• 4 Clinical Trials of Cardiovascular Regeneration Therapy Using Granulocyte Colony-Stimulating Factor(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Effect of Granulocyte Colony-Stimulating Factor Treatment at a Low Dose but for a Long Duration in Patients With Coronary Heart Disease : A Pilot Study
• Postinfarction Treatment With Edaravone, a Free Radical Scavenger, Reduces Myocardial Infarct Size, Improves Cardiac Function and Remodeling in Rabbits(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese C
• Dual blockade of the rennin-angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis
• Critical Roles of Fas/Fas Ligand Interaction and Beneficial Effect of Soluble Fas Gene Therapy for Post-lnfarct Ventricular Remodeling and Dysfunction
• Critical roles of the Fas/Fas ligand system for post-infarct ventricular remodeling and heart failure
• Injection of an adenoviral vector expressing hepatocyte growth factor into skeletal muscle after myocardial infarction relieves post-infarct heart failure
• Improvement of Left Ventricular Function by Granulocyte Colony-Stimulating Factor in Patients with Acute Myocardial Infarction(Acute Myocardial Infarction, Clinical (Diagnosis/Treatment) 7 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulat
• FRS-116 Evaluation of G-CSF Regeneration Therapy in Patients with Old Myocardial Infarction Using TI-201 SPECT Imaging(Nuclear Cardiology (I) : FRS14)(Featured Research Session (English))
• G-CSF Therapy for Therapeutic Angiogenesis in Patients with Ischemic Heart Disease : Evaluation Using TI-201 SPECT Imaging
• Long-Term and Strict Blood Pressure Lowering by Imidapril Reverses Left Ventricular Hypertrophy in Patients with Essential Hypertension : An Evaluation Using a Novel Indicator of Burden on the Left Ventricle
• Relationship between thallium-201 myocardial SPECT and findings of endomyocardial biopsy specimens in dilated cardiomyopathy
• Sheng-Mai-San is Protective Against Post-Ischemic Myocardial Dysfunction in Rats Through Its Opening of the Mitochondrial KATP Channels
• Celiprolol, a β 1-blocker, reduces myocardiat infarct size not through mitochondrial KATP channel opening but through nitric oxide production in rabbits
• Shen-Mai-San is protective against post-ischemic myocardial dysfunction through scavenging hydroxyl radicals and opening the mitochondrial KATP channels in rats
• Protective Effect of a Novel Anti-Diabetic Drug, Miglitol, an α-Glucosidase Inhibitor, Against Anginal Ischemia in a Canine Model
• Comparison of Biochemical Data, Blood Pressure and Physical Activity Between Longevity and Non-Longevity Districts in Japan
• THE ROLE OF PLASMA CONJUGATED NORADRENALINE(NAc)IN PATIENTS WITH CARDIAC DISEASES : AN INVESTIGATION OF THE CONVERSION TO FREE FORM AND THE SITE OF DECONJUGATION
• PJ-737 Long-Term and Strict Blood Pressure Lowering by Imidapril Reverses Left Ventricular Hypertrophy in Patients with Essential Hypertension(Cardiac hypertrophy, basic/clinical-4 (M) PJ125,Poster Session (Japanese),The 70th Anniversary Annual Scientific
• Combination of N-Methyl-1-Deoxynojirimycin and Ischemic Preconditioning Markedly Reduces the Size of Myocardial Infarcts in Rabbits
• Benefits of quantitative gated SPECT in evaluation of perioperative cardiac risk in noncardiac surgery
• Prognostic Effects of Calcium Channel Blockers in Patients With Vasospastic Angina : A Meta-Analysis
• Ultrastructure of regenerated cardiac cells after myocardial infarction : Differentiation, proliferation, and apoptosis
• Tumor necrosis factor-α(TNF) exacerbates myocardial ischemia/reperfusion (I/R) injury, but partially reduces infarct size after permanent myocardial ischemia in mice
• Cardiac remodeling after myocardial infarction in mice lacking matrix metalloproteinase-2 (MMP-2)
• Open-label, Randomized Crossover Study Between Telmisartan and Valsartan on Improving Insulin Resistance and Adipocytokines in Nondiabetic Patients with Mild Hypertension
• Sarpogrelate, serotonin blocker, protects myocardial ischemic injury in patients with coronary artery disease
• Apoptosis, Rather Than Oncosis, is the Predominant Mode of Spontaneous Death of Isolated Adult Rat Cardiac Myocytes in Culture
• Hydroxyl Radical Generation by the Combination of Iron and Ascorbic Acid is Greatly Attenuated but Still Significant in Human Grastric Juice

もっと見る 閉じる

スポンサーリンク