MODULATION OF NORADRENALINE RELEASE VIA ACTIVATION OF PRESYNAPTIC β-ADRENOCEPTORS IN RABBITS WITH ADRIAMYCIN-INDUCED CARDIOMYOPATHY
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概要
- 論文の詳細を見る
We investigated the role of β-adrenoceptors at postganglionic sympathetic nerve endings in noradrenaline release in rabbits with cardiomyopathic congestive heart failure produced by adriamycin (1 mg/kg, I.V., twice a week for 8 weeks). Plasma noradrenaline levels were measured before, 30 min after, and 60 min after the start of continuous intravenous administration of adrenaline (0.06μg/kg/min) in adriamycin-treated and vehicle-treated rabbits in anesthetized condition and pithed condition with electrically stimulated sympathetic outflow (3 Hz, 1 ms square wave pulse, 90 V). In both the anesthetized and pithed conditions, adrenaline increased plasma noradrenaline levels in vehicle-treated rabbits. However, in the adriamycin-treated rabbits, adrenaline had no effect on the plasma noradrenaline level. Pretreatment with propranolol (0.2 mg/kg, bolus I.V. + 0.1 mg/kg/hr, continuous infusion) almost completely abolished the rise in plasma noradrenaline associated with adrenaline infusion in vehicle-treated rabbits. These results suggest that in rabbits with adriamycin-induced cardiomyopathy, the noradrenaline release from the sympathetic nerve endings via the activation of presynaptic β-adrenoceptors is reduced. This might be due to down-regulation of presynaptic β-adrenoceptors caused by the elevated plasma noradrenaline due to cardiac failure. However, other possibilities such as reduced affinity or impaired signal transduction cannot be excluded.
- 1993-05-20
著者
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Hirose Isao
The Second Department Of Internal Medicine Gifu University School Of Medicine
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Kawasaki Masanori
Gifu University Graduate School of Medicine
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MINATOGUCHI Shinya
Department of Cardiology, Gifu University Graduate School of Medicine
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YOKOYAMA Hitomi
Second Department of Internal Medicine, Gifu University School of Medicine
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KAKAMI Masao
Second Department of Internal Medicine, Gifu University School of Medicine
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Uno Yoshihiro
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Me
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Minatoguchi Shinya
Department Of Cardiology Gifu University Graduate School Of Medicine
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Minatoguchi Shinya
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Uno Yoshihiro
Department Of Cardiology Gifu University Graduate School Of Medicine
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Ito Hiroyasu
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Itoh Hiroyasu
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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ITO Hiroyasu
Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine
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IMAI Yoko
Department of Chemistry, Faculty of Engineering, Kanagawa University
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Ito Hiroyasu
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Kakami Masao
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Uno Yoshihiro
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa S
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
Department Of Medicine Gifu University School Of Medicine
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Ito Hiroyasu
The Second Department Of Internal. Medicine Gifu University School Of Medicine
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IMAI YOKO
The 2nd Department of Internal Medicine, Gifu University School of Medicine
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Hirakawa Senri
The Second Department Of Medicine Gifu University School Of Medicine
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Hirakawa Senri
Dept. Of Intern. Med. Gifu Univ. School Of Med.
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Hirakawa Senri
2nd. Dept. Of Intern. Med Gifu Univ. School Of Med
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Imai Yoko
Department Of Chemistry Faculty Of Engineering Kanagawa University
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Imai Yoko
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Koshiji Masatoshi
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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KOSHINO MASATOSHI
Department of Internal Medicine Gifu University School of Medicine
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KAKAMI MASAO
Department of Internal Medicine Gifu University School of Medicine
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YOKOYAMA HITOMI
Department of Internal Medicine Gifu University School of Medicine
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Yokoyama Hitomi
Second Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
岐阜大学 第2内科
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Ito Hiroyasu
Department Of Informative Clinical Medicine Gifu University Graduate School Of Medicine
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Hirakawa Senri
Second Department Of Internal Medicine Gifu University School Of Medicine.
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Ito Hiroyasu
Department Of Frontier Materials Nagoya Institute Of Technology
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Hirakawa Senri
Dept. Of Med. 2 Gifu Univ. School Of Med
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Hirakawa Senri
The 2 Depart. Of Intern. Med. Gifu Univesity Of Med.
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KOSHINO MASATOSHI
The 2^ Department of Internal Medicine Gifu University School of Medicine
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YOKOYAMA HITOMI
The 2^ Department of Internal Medicine Gifu University School of Medicine
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