INCREASE IN PLASMA NORADRENALINE CONCENTRATION AFTER THE ADMINISTRATION OF PHENTOLAMINE IN THE PATIENTS WITH "LATENT" LEFT-SIDED HEART FAILURE
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概要
- 論文の詳細を見る
We measured increments of peripheral venous pressure induced by dynamic leg exercise (ΔVP) in 10 healthy subjects (Group C) and 70 patients with heart diseases which primarily affect the left-side of the heart. None of the subjects showed apparent symptoms of left- or right-sided heart failure. The patients were divided into 2 groups on the basis of ΔVP, namely, Group N (ΔVP<35 mmH_2O, n=30, normal reaction) and Group H (ΔVP≧35 mmH_2O, n=40, abnormal reaction). We measured the increments of plasma concentrations of noradrenaline (ΔNA_<PH>) and adrenaline (ΔA_<PH>) with infusion of phentolamine (PH). Parallel studies with nitroglycerin and prozosin supplied strong evidence that ΔNA_<PH> was brought about mainly by the blockade of α_2-receptors at the sympathetic nerve terminals. Thus, we estimated the degree of sympathetic nerve activity from the central nervous system by opening using PH the negative feed-back loop for noradrenaline (NA) release at the sympathetic nerve terminals, and this degree of sympathetic nerve activity was compared with the degree of ΔVP. The results obtained were 1) there was a rough overall correlation between ΔVP and ΔNA_<PH> in the subjects of Groups C, N and H, and 2) ΔNA_<PH> was significantly higher in Group H than in Groups C and N. These results suggest that much reliance can be placed on the measured increment of plasma NA concentration in response to the administration of PH in assessing the degree of enhanced sympathetic nerve activity in the patients with "latent" left-sided heart failure.
- 社団法人日本循環器学会の論文
- 1989-12-20
著者
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Hirose Isao
The Second Department Of Internal Medicine Gifu University School Of Medicine
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Ito Hiroyasu
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Minatoguchi Shinya
The second Department of Internal Medicine, Gifu University School of Medicine
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Itoh Hiroyasu
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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HIRAKAWA SENRI
The Second Department of Internal Medicine, Gifu University School of Medicine
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ITO HIROYASU
The Second Department of Internal Medicine, Gifu University School of Medicine
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Ito Hiroyasu
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa S
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
The Second Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
The 2nd Department Of Internal Medicine Gifu University School Of Medicine
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Watanabe H
Kawasaki Univ. Medical Walfare Okayama Jpn
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Suzuki Shinya
The Second Department Of Internal Medicine Gifu University School Of Medicine
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WATANABE HIROKO
The Second Department of Internal Medicine, Gifu University School of Medicine
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IMAI YOKO
The Second Department of Internal Medicine, Gifu University School of Medicine
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KOSHIJI MASATOSHI
The Second Department of Internal Medicine, Gifu University School of Medicine
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SUZUKI SAKURA
The Second Department of Internal Medicine, Gifu University School of Medicine
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IMAMURA KOJI
The Second Department of Internal Medicine, Gifu University School of Medicine
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Ito Hiroyasu
The Second Department Of Internal. Medicine Gifu University School Of Medicine
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Hirakawa Senri
The Second Department Of Medicine Gifu University School Of Medicine
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ISHIMURA Koji
2nd Department of Internal Medicine,Gifu University
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Hirakawa Senri
Dept. Of Intern. Med. Gifu Univ. School Of Med.
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Ishimura Koji
2nd Department Of Internal Medicine Gifu University
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Hirakawa Senri
2nd. Dept. Of Intern. Med Gifu Univ. School Of Med
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Imai Yoko
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Koshiji Masatoshi
The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
岐阜大学 第2内科
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Minatoguchi Shinya
The Second Department Of Internal Medicine Gifu University Graduate School Of Medicine
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Hirakawa Senri
Second Department Of Internal Medicine Gifu University School Of Medicine.
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Hirakawa Senri
Dept. Of Med. 2 Gifu Univ. School Of Med
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Ito Hiroyasu
The Second Department Of Internal Medicine Gifu University School Of Medicine
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Hirakawa Senri
The 2 Depart. Of Intern. Med. Gifu Univesity Of Med.
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