VOLUME-PRESSURE RELATIONS OF THE HUMAN PULMONARY "VENOUS" SYSTEM STUDIED BY RADIONUCLIDE ANGIOCARDIOGRAPHY AND PASSIVE LEG ELEVATION, WITH SPECIAL REFERENCE TO THE EFFECT OF NITROGLYCERIN

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• In an attempt to clarify the effect of nitroglycerin (NTG) on the human pulmonary "venous" (P"V") system, short segments of volume-pressure (V-P) curves in the P"V" system were estimated in 50 patients before and after the sublingual administration of NTG. The pulmonary "venous" volume (P"V"V) was estimated with our own method, using radionuclide (RN) angiocardiography. The mean pulmonary artery wedge pressure (<PAW>^^^-) was measured using a Swan-Ganz catheter. The increments of P"V"V and <PAW>^^^- that occurred during passive elevation of the legs were clues to the estimation of V-P "curves" in this system before and after NTG. In order to calculate a short segment of a V-P curve, the P"V"V was plotted on the ordinate and the <PAW>^^^- on the abscissa. In addition, we presented the effective unstressed volume graphically by extrapolating each short segment of V-P curves towards the volume axis (ordinate). We obtained the following results from the present study; (1) The sublingual administration of NTG caused the P"V"V-<PAW>^^^--plots to shift to the left (-5.2 ± 3.6 mmHg, mean ± SD) and downwards (-19 ± 11 ml, mean ± SD). (2) The V-P curves appeared to shift steeper after NTG (19.2 ± 11.3 ml/mmHg, mean ± SD) than before NTG (12.4 ± 7.9 ml/mmHg). (3) The graphically-obtained effective unstressed volume was unchanged with NTG, at least within the operating range of <PAW>^^^-. (4) It is highly probable that NTG causes the tone of the P"V" system to be decreased by way of a relaxation of the vascular beds of the P"V" system.

• 社団法人日本循環器学会の論文
• 1986-04-20

著者

• Suzuki Takahiko

  Toyohashi Heart Center

• TAKATSU Hisato

  Second Department of Internal Medicine, Gifu University School of Medicine

• Fujiwara Hisayoshi

  岐阜大学 第2内科

• YASUDA YUKIO

  Central Institute for Experimental Animals

• Suzuki Takahiko

  2nd Department Of Internal Medicine Gifu University

• Gotoh Kohshi

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• HIRAKAWA SENRI

  The Second Department of Internal Medicine, Gifu University School of Medicine

• SUZUKI TAKAHIKO

  The Second Department of Internal Medicine, Gifu University School of Medicine

• OHSUMI YUKIO

  The Second Department of Medicine Gifu University School of Medicine

• TAKATSU HISATO

  The Second Department of Medicine Gifu University School of Medicine

• YAGI Yasuo

  The Second Department of Internal Medicine,Gifu University School of Medicine

• GOTOH KOSHI

  The Second Department of Internal Medicine, Gifu University School of Medicine

• FUJIWARA HIDEKI

  The Second Department of Internal Medicine, Gifu University School of Medicine

• Yasuda Y

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Ohsurni Yukio

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Ohsumi Yukio

  Department Of Cardiology Hashima City Hospital

• Hirakawa Senri

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Suzuki Takahiko

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Yagi Yasuo

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Yasuda Yo

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Osumi Yukio

  Second Department Of Internal Medicine Gifu University School Of Medicine

• Ohsumi Yukio

  The Second Department Of Internal. Medicine Gifu University School Of Medicine

• Goto Koshi

  The Second Department Of Internal. Medicine Gifu University School Of Medicine

• Fujiwara Hideki

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Takatsu Hisato

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Takatsu Hisato

  First Department Of Internal Medicine Gifu Municipal Hospital

• Suzuki Takehiko

  Toyohashi Heart Center

• Hirakawa Senri

  2nd. Dept. Of Intern. Med Gifu Univ. School Of Med

• Goto Koshi

  The Second Department Of Medicine Gifu University School Of Medicine

• Hirakawa Senri

  岐阜大学 第2内科

• Hirakawa Senri

  Second Department Of Internal Medicine Gifu University School Of Medicine.

• Suzuki Takehiko

  The 2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Fujiwara Hideki

  The 2nd Dept Of Intern. Med. Gifu Univ. School Of Med

• Hirakawa Senri

  The 2 Depart. Of Intern. Med. Gifu Univesity Of Med.

• Goto Koji

  The 2 Depart. Of Intern. Med. Gifu Univesity Of Med.

• Yasuda Yo

  岐阜大学 第2内科

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