Non-invasive Estimation of the Human Pulmonary Blood Volume with Gamma Camera and RI-angiocardiography : The Present Status of Cordiovascular Nuclear Medicine

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A new, non-invasive method for the estimation of the human pulmonary blood volume (PBV), existing between the pulmonary artery bifurcation (PAB) and the left atrium (LA), has been developed in this laboratory, in the form of PBV = PPT_<RCG x> × 0.77 × CO, equation (6), given in Appendix. This was an extension of the classical Stewart-Hamilton method of indicator dilution, applied to radioisotope angiocardiography. Using a gammacamera, the radio-isotope (99m Tc-albumin) dilution curves were recorded externally at the region of PAB, LA and LV (left ventricle), among other things, in human subjects in supine position. The mean transit time (MTT) was determined for each region, and the difference in MTT, e. g., ΔMTT_<PAB-LA>, was measured. We calculated PBV between PAB and LA as PBV = ΔMTT_<PAB-LA> x CO, equation ( I ) given in Appendix. Empirical time relations between ΔMTT_<PAB-LA> and PPT_<RCG> were examined in mechanical models and human subjects, through several steps represented by equations (2) to (5), given in Appendix, and our tentatively final formula was equation (6). The values of PBV estimated in this way were in good agreement with those of PBV measured invasively in the past, using two injection sites (PA and LA) and one sampling site (artery).
社団法人日本循環器学会の論文
1981-01-20