INHIBITORY ACTION OF PROPRANOLOL AND ITS STEREOISOMERS ON EPINEPHRINE-INDUCED CHANGES IN ELECTROCARDIOGRAM

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概要

• 論文の詳細を見る

• Isoproterenol, epinephrine, and norepinephrine, intracoronarily injected with the coronary artery catheterization, produced a. marked "ischemic" change in ECG, while phenylephrine failed to do so. This change was inhibited by the pretreatment with propranolol, but not by that with phenoxybenzamine. No marked change was produced in the coronary blood flow by these catecholamines, but a change occurred in blood pressure pulse pattern recordable from the carotid artery in association with ECG changes. When the magnitude of the "ischemic" change in ECG produced by graded-dose administration of epinephrine was quantitated in terms of ST・T-Area, it was found that the change in ST・T-Area depended on the dose of epinephrine used; norepinephrine produced changes in ECG with nearly equal potency to epinephrine. ECG changes caused by epinephrine in dose of 1 μg was completely inhibited by the pretreatment with about 125 μg of DL-propranolol, L-propranolol or ICI 50172, but 400 μg of D-propranolol was required to produce the same blocking effect. On the other hand, procaine had no such inhibitory effect. From these results it is suggested that the epinephrine-induced ECG changes of "ischemic" type appear to represent a beta-adrenergic response. When the ST and T changes were quantitated in terms of ST・T-Area, propranolol exerted a blocking action on such epinephrine-induced ECG changes, and D-propranolol was one third as potent in this respect as L-propranolol.

• 社団法人日本循環器学会の論文
• 1972-12-20

著者

• Ito Hiroyasu

  The 2nd Department Of Internal Medicine Gifu University School Of Medicine

• HIRAKAWA SENRI

  The Second Department of Internal Medicine, Gifu University School of Medicine

• Hirakawa Senri

  The 2nd Department of Internal Medicine, Gifu University School of Medicine

• ITO HIROYASU

  The Second Department of Internal Medicine, Gifu University School of Medicine

• Ito Hiroyasu

  The 2^<nd> Department Of Internal Medicine Gifu University School Of Medicine

• Kondo Yasushi

  The 2nd Department Of Medicine Gifu University School Of Medicine

• Hirakawa Senri

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Ito Hiroyasu

  The Second Department Of Internal. Medicine Gifu University School Of Medicine

• Hirakawa Senri

  The 2nd Department Of Lnternal Medicine Gifu University School Of Medicine

• Yosimura Tsuyosi

  Dept. Of Intern. Med. Gifu Univ. School Of Med.

• Watanabe Ikuo

  2nd Dept. of Intern. Med, Gifu Univ. School of Med

• Hayase Shoji

  Dept. of Intern. Med. Gifu Univ. School of Med.

• Hayase Shoji

  2nd Dept. Of Intern. Med Gifu Univ. School Of Med

• Hayase Shoji

  2nd Dept Of Intern. Med Gifu Univ. School Of Med.

• Watanabe Ikuo

  2nd Dept. Of Intern. Med Gifu Univ. School Of Med

• Yoshimura Tsuyoshi

  The Second Division Department Of Internal Medicine School Of Medicine Gifu University

• HAYASE SHOJI

  The Second Division, Department of Internal Medicine, School of Medicine, Gifu University

• KONDO YASUSHI

  The Second Division, Department of Internal Medicine, School of Medicine, Gifu University

• IMAO TAIICHIRO

  The Second Division, Department of Internal Medicine, School of Medicine, Gifu University

• WATANABE IKUO

  The Second Division, Department of Internal Medicine, School of Medicine, Gifu University

• Imao Taiichiro

  The Second Division Department Of Internal Medicine School Of Medicine Gifu University

• Hirakawa Senri

  The 2nd Dep. Of Int. Med. Gifu Univ. School Of Med.

• Ito Hiroyasu

  The Second Department Of Internal Medicine Gifu University School Of Medicine

• Hayase Shoji

  Dept. Of Med. 2 Gifu Univ. School Of Med

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