Comparison of Biochemical Data, Blood Pressure and Physical Activity Between Longevity and Non-Longevity Districts in Japan
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概要
- 論文の詳細を見る
Background There is controversy about longevity-associated factors, including environmental and genetic factors. Clinical and epidemiological studies suggest that multiple risk factors decrease life-span, but there has not been a definitive report regarding the association of risk factors with longevity. The ultimate aim of the present study was to prevent the overwhelming increase in life-style-related diseases by evaluating this association in 2 districts in Japan. Methods and Results Plasma glucose levels, hemoglobin (Hb) A1c, lipids, dehydroepiandrosterone-sulfate, adiponectin and physical activity were examined in 133 subjects (M/F 47/86, 67±1 years) in Kokufu, a longevity district (mean life span: 80.4 years according to 2000 Japanese census) and 69 subjects (M/F 29/40, 62±1 years) in Miyama, a non-longevity district (mean life span 77.4 years, 2000 census). There were significant differences in systolic and diastolic blood pressures (BPs, p<0.001), exercise capacity (p<0.0001) and plasma adiponectin levels (p<0.04) between the districts. Plasma adiponectin level was significantly correlated with high-density lipoprotein-cholesterol (HDL-C) (r=0.333, p<0.0001), triglyceride (TG) (r=-0.161, p<0.04), HbA1c (r=-0.163, p<0.03) and HOMA-R (r=-0.163, p<0.03). Conclusion Life-style-related factors such as BP, exercise capacity and plasma adiponectin levels might play an important role in longevity, and those of HDL-C and TG, as well as glucose tolerance, might be associated with adiponectin levels. (Circ J 2008; 72: 1680 - 1684)
- 社団法人日本循環器学会の論文
- 2008-09-20
著者
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Uno Yoshihiro
Department of Cardiology, Regeneration Medicine and Bioethics, Gifu University Graduate School of Me
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Uno Yoshihiro
Department Of Cardiology Gifu University Graduate School Of Medicine
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Uno Yoshihiro
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Morita Hiroyuki
Department of Translational Research for Healthcare and Clinical Science, Graduate School of Medicin
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Morita H
Department Of System Engineering Of Materials And Life Science Faculty Of Engineering Toyama Univers
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Morita H
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Mori Ichiro
Department of Pathology, Wakayama Medical University
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MATSUMOTO MASAMI
Department of Internal Medicine, Nara Prefectural Gojo Hospital
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Matsubara Kenji
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Kazita Kazuo
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Ishizuka Tatsuo
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Morita Hiroyuki
The Department Of General Medicine
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Morita Hiroyuki
Department Of Cardiovascular Medicine Graduate School Of Medicine University Of Tokyo
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Kajita Kazuo
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Ikeda Takahide
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Fujioka Kei
Department of General Internal Medicine, Gifu University Graduate School of Medicine
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Matsumoto Masami
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Fujioka Kei
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Kazita Kazuo
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Ikeda Takahide
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Ishizuka Tatsuo
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Ishizuka Tatsuo
The Third Department Of Internal Medicine Gifu University School Of Medicine
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Mihara H
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Mori Ichiro
Department Of Cardiovascular Medicine The University Of Tokyo
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Matsubara Kenji
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Morita Hiroyuki
Third Department Of Internal Medicine Gifu University School Of Medicine
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Matsumoto Masami
Department Of Biology Faculty Of Science Yamagata University
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Mori Ichiro
Department Of General Internal Medicine Gifu University Graduate School Of Medicine
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Kajita Kazuo
The Third Department Of Internal Medicine Gifu University School Of Medicine
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Mori Ichiro
Department Of Cardiology The University Of Tokyo
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Morita Hiroyuki
Department of Artificial Organ, Chukyo Hospital
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