New Cyclization Mechanism for Squalene : a Ring-expansion Step for the Five-membered C-ring Intermediate in Hopene Biosynthesis
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概要
- 論文の詳細を見る
Three triterpenes having the 6/6/5-fused tri- and 6/6/6/5-fused tetracyclic skeletons were isolated from an incubation mixture of the mutated F601A enzyme, these products being in accordance with a Markovnikov closure. Successful trapping of the tricyclic cationic intermediate by using the squalene analog having a highly nucleophilic hydroxyl group leads us to propose that the ring expansion process of the 5-membered C-ring is involved in the squalene cyclization cascade.
- 社団法人日本農芸化学会の論文
- 1999-11-23
著者
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HOSHINO Tsutomu
Department of Applied Biological Chemistry, Faculty of Agriculture and Graduate School of Science an
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Ohashi S
Hokkaido Univ. Hokkaido Jpn
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KOUDA Masanori
Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science T
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ABE Takamasa
Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduate School of Science T
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OHASHI Shumi
Department of Applied Biological Chemistry, Faculty of Agriculture, and Graduated School of Science
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Abe Takamasa
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduate School Of Science Tec
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Kouda M
Niigata Univ. Niigata Jpn
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Kouda Masanori
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduate School Of Science And
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Ohashi Shumi
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduated School Of Science Te
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Hoshino Tsutomu
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduate School Of Science And
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Hoshino Tsutomu
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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Hoshino Tsutomu
Department Of Applied Biological Chemistry Faculty Of Agriculture And Graduate School Of Science Tec
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