Stimulation by Bovine Lactoferrin of Nerve Growth Factor Synthesis/Secretion in Mouse L-M Cells
スポンサーリンク
概要
- 論文の詳細を見る
Cultured mouse fibroblasts synthesize and secrete nerve growth factor (NGF). To learn the mechanism of action of an iron-binding protein, lactoferrin (Lf), on cultured animal cells, we have examined the effects of bovine Lf (bLf) on NGF synthesis/secretion in mouse L-M cells, a line derived from L929 fibroblast cells. Both apo- and holo-bLf induced an increase in NGF content in the cell-conditioned medium (CM) with similar effectiveness. Neither apo- nor holo- bovine transferrin (bTf) was effective, indicating that the observed induction of NGF production cannot be attributed to stimulation of iron transport. A basic peptide fragment of bLf (residues 17-41) isolated from a pepsin hydrolyzate of bLf was found to be effective for stimulation of NGF synthesis/secretion in L-M cells. This observation demonstrates that the basic nature of Lf is important for its interaction with fibroblast cells.
- 社団法人日本農芸化学会の論文
- 1993-06-23
著者
-
Shinoda Ichizo
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
-
Fukuwatari Yasuo
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
-
Shimamura Seiichi
Nutritional Science Laboratory, Morinaga Milk Industry Co., Ltd.
-
Shinoda Ichizo
Department Of Fermentation Technology Faculty Of Engineering Hiroshima University
-
Shinoda Ichizo
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
-
Shinoda Ichizo
森永乳業
-
Fukuwatari Yasuo
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
-
Fukuwatari Y
Morinaga Milk Ind. Co. Ltd. Kanagawa Jpn
-
Tomita Mamoru
Food Research & Development Laboratory Morinaga Milk Industry Co. Ltd.
-
Shimamura Seiichi
Nutritional Science Laboratory Morinaga Milk Industry Co. Ltd.
関連論文
- Effects of Lactoferrin and Its Peptides on Proliferation of Rat Intestinal Epithelial Cell Line, IEC-18, in the Presence of Epidermal Growth Factor
- Endogenous Oxygen Uptake and Polysaccharide Accumulation in Bifidobacterium(Microbiology & Fermentation Industry)
- The Bacteriostatic Effects of Orally Administered Bovine Lactoferrin on Intestinal Enterobacteriaceae of SPF Mice Fed Bovine Milk
- Effects of Orally Administered Bovine Lactoferrin on the Faecal Enterobacteriaceae of SPF Mice Fed Milk
- Effects of Lactoferrin and Lactoferricin^ on the Release of Interleukin 8 from Human Polymorphonuclear Leukocytes
- Stimulation by Bovine Lactoferrin of Nerve Growth Factor Synthesis/Secretion in Mouse L-M Cells
- Induction of an Increase in Nerve Growth Factor Content in the Cell-conditioned Medium of Mouse L-M Cells by Basic Peptides
- Identification and Molecular Analysis of Lactococcus lactis rpoD Operon
- Genetic and Molecular Analysis of the rpoD Gene from Lactococcus lactis
- Effects of Pressure on Enzyme Activities of Lactobacillus helveticus LHE-511
- A Mechanism for Bitter Taste Sensibility in Peptides(Food & Nutrition)
- Taste of Proline-containing Peptides(Food & Nutrition)
- Role of the Hydrophobic Amino Acid Residue in the Bitterness of Peptidest(Food & Nutrition)
- Bitter Taste of H-Pro-Phe-Pro-Gly-Pro-Ile-Pro-OH Corresponding to the Partial Sequence (Positions 61〜67) of Bovine β-Casein, and Related Peptide(Food & Nutrition)
- Bitterness of Diastereomers of a Hexapeptide (Arg-Arg-Pro-Pro-Phe-Phe) Containing D-Phenylalanine in Place of L-Phenylalanine(Food & Nutrition)
- Bitter Taste of H-Val-Val-Val-Pro-Pro-Phe-Leu-OH Corresponding to the Partial Sequence (Positions 82〜88) of Bovine β-Casein, and Related Peptides(Food & Nutrition)
- Effect of Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers
- Variation in Bitterness Potency When Introducing Gly-Gly Residue into Bitter Peptides
- Inhibitory Effects of Human-Derived Bifidobacterium on Pathogenic Escherichia coli Serotype O-111
- Effect of Iron-Free and Metal-Bound Forms of Lactoferrin on the Growth of Bifidobacteria, E. coli and S. aureus
- Bitter Taste of Synthetic C-Terminal Tetradecapeptide of Bovine β-Casein, H-Pro196-Val-Leu-Gly-Pro-Val-Arg-Gly-Pro-Phe-Pro-Ile-Ile-Val209-OH, and Its Related Peptides
- Studies on a Model of Bitter Peptides Including Arginine, Proline and Phenylalanine Residues. II.1) Bitterness Behavior of a Tetrapeptide (Arg-Pro-Phe-Phe) and Its Derivatives
- Studies on a Model of Bitter Peptides Including Arginine, Proline and Phenylalanine Residues. I. Bitter Taste of Di- and Tripeptides, and Bitterness Increase of the Model Peptides by Extension of the Peptide Chain