Acute Massive Pulmonary Thromboembolism Associated With Risperidone and Conventional Phenothiazines
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概要
- 論文の詳細を見る
To assess the contribution of antipsychotic medication in Japanese patients suffering acute massive pulmonary thromboembolism, records of patients with idiopathic pulmonary thromboembolism associated with antipsychotic medication who were seen in a Japanese Emergency Center from January 1996 to December 2000 were reviewed. Age, gender, physical status, clinical presentation, antiphospholipid antibody, outcome, psychiatric profile, and antipsychotic medication use were examined. Seven patients had acute pulmonary thromboembolism associated with antipsychotic drug use, representing 44% of all patients with idiopathic pulmonary thromboembolism. The 7 patients developed symptoms in the early morning. More women than men were affected. In 5 cases, chlorpromazine and other phenothiazines had been prescribed, whereas in 2 cases, risperidone, a mixed serotonin 5HT_2A and dopamine D_2 receptor antagonist, had been taken for 40 days and 6 days, respectively. In 4 cases, including the patients taking risperidone, antiphospholipid antibodies were not present. Although statistically significant conclusions can not be drawn from this study, the data suggest that patients receiving risperidone, as well as conventional phenothiazines, are at risk for acute pulmonary thromboembolism, even if otherwise healthy. Strong affinity for the 5HT_2A receptor of the novel antipsychotic may increase coagulability and the risk of thromboembolism.
- 社団法人日本循環器学会の論文
- 2002-12-20
著者
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SOMA Kazui
Departments of Cardio-angiology and Emergency and Critical Care Medicine, Kitasato University School
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Soma Kazui
Department Of Emergency And Critical Care Medicine Kitasato University School Of Medicine
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OHWADA Takashi
Department of Emergency Medicine, Kitasato University School of Medicine
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Nagai Tomonori
Department of Legal Medicine, Kitasato University School of Medicine
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Kurihara Katsuyoshi
Department of Legal Medicine, Kitasato University School of Medicine
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Kurihara Katsuyoshi
Department Of Legal Medicine Kitasato University School Of Medicine
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Nagai Tomonori
Department Of Electronics And Information Science Teikyo University Of Science And Technology
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Ohwada Takashi
Department Of Critical Care And Emergency Medicine Kitasato University School Of Medicine
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Ohwada Takashi
Departments Of Emergency And Critical Care Medicine
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Kamijo Yoshito
Departments of Emergency and Critical Care Medicine
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Soma Kazui
Department Of Critical Care And Emergency Kitasato University School Of Medicine
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Kamijo Yoshito
Department Of Emergency And Critical Care Medicine Kitasato University School Of Medicine
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Kurihara Katsuyoshi
Department of Legal Medicine, Kitasato University, School of Medicine
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Nagai Tomonori
Department of Legal Medicine, Kitasato University, School of Medicine
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Kamijo Yoshito
Department of Emergency & Critical Care Medicine, School of Medicine, Kitasato University of Kanagawa, Japan
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