Hemodynamic Effects of Phosphodiesterase III Inhibitor in Patients With a Large Ventricular Left-to-Right Shunt
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概要
- 論文の詳細を見る
The hemodynamic effects of olprinone, a newly synthesized phosphodiesterase(PDE) III inhibitor, were assessed in patients with a large codiac left-to-right shunt. Ten patients with a large ventricular septal defect(VSD) were evaluated during cardiac catheterization. Olprinone was administered as a bolus, 20μg/kg body weight, and hemodynamic data were obtained before and after the administration. Heart rate and systemic flow increased significantly after administration. On the other hand, olprinone significantly reduced left and right atrial pressure, the systolic pulmonary/arterial pressure ratio, and systemic vascular resistance. However, pulmonary flow and pulmonary vascular resistance were not changed. These results suggested that olprinone had a positive inotropic effect and selective vasodilator effect on patients with a large ventricular left-to-right shunt. Thus, PDE inhibitors may be beneficial for the treatment of patients with a large VSD.
- 社団法人日本循環器学会の論文
- 2000-03-20
著者
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SATO TOMOKO
Department of Bioresource Science, Faculty of Agriculture, Kagawa University
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Suzuki Hitoshi
Department of Cardiology and Hematology, Fukushima Medical University
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Sato Kei
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University
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Momoi Nobuo
Department Of Pediatrics Fukushima Medical University School Of Medicine
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SUZUKI Hideki
Department of Medical Information, Gunma Prefectural College of Health Sciences
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Kobayashi Tomoyuki
Department Of Pediatrics Fukushima Medical University
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Sato Tomoko
Department Of Pediatrics Fukushima Medical University
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Sato Morihiro
Department of Electrical Engineering , Faculty ofEngineering,Himeji Institute of Technology
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Sato Morihiro
Department Of Pediatrics Fukushima Medical University
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Kobayashi Tomoyuki
Department Of Earth Sciences Graduate School Of Sciences Chiba University
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Suzuki Hideki
Department Of Pediatrics Fukushima Medical University School Of Medicine
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Sato Kei
Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kyushu University
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Suzuki Hitoshi
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Kobayashi Tomoyuki
Department Of Earth Sciences Graduate School Of Science Chiba University
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SUZUKI Hideki
Department of Agricultural Chemistry, The University of Tokyo
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Momoi Nobuo
Department of Pediatrics, Fukushima Medical University, School of Medicine
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MOMOI NOBUO
Department of Pediatrics
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