FLOW-MEDIATED DILATATION IDENTIFIES IMPAIRED ENDOTHELIAL FUNCTION IN PATIENTS WITH SLEEP APNEA SYNDROME
スポンサーリンク
概要
- 論文の詳細を見る
[Background] Non-invasive detection of vascular dysfunction in the early stage is clinically important in patients with sleep apnea syndrome (SAS). Flow-mediated dilatation (FMD) is a novel clinical marker of endothelial function. However, it is not clear whether this is useful in the SAS patient. [Methods] Echocardiographic parameters and FMD were measured in 129 patients with SAS. Apnea-hypopnea index (AHI) was defined by polygraphy, and patients were divided into the two Groups: Group A (moderate-severe SAS: AHI≥ 15 times/hr, n=93) and Group B (mild SAS: AHI 5-15 times/hr, n=36). [Results] There were no significant differences in echocardiographic parameters between the two groups. However, FMD was significantly lower in Group A than in Group B (3.5±1.6 vs. 7.8±3.1, P< 0.01). [Conclusions] Although cardiac function was not different, vascular dysfunction was evident in patients with moderate-severe SAS. FMD is a useful tool to identify impaired endothelial function non-invasively in patients with SAS.
著者
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Ishibashi Toshiyuki
Department Of Cardiology And Hematology Fukushima Medical University
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Sugimoto Koichi
Department Of Cardiology And Hematology Fukushima Medical University
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Suzuki Hitoshi
Department of Cardiology and Hematology, Fukushima Medical University
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Sakamoto Nobuo
Department of Biomedical Chemistry, School of Medicine, Nagoya University
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Owada Takashi
Department Of Neurosurgery Hokkaido University School Of Medicine
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Misaka Tomofumi
Department Of Cardiology And Hematology Fukushima Medical University
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Suzuki Hitoshi
Department Of Animal Science Faculty Of Agriculture Tohoku University
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Suzuki Satoshi
Department Of Advanced Cardiac Therapeutics Fukushima Medical University
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NAKAZATO Kazuhiko
Department of Cardiology and Hematology, Fukushima Medical University
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SAITOH Shu-ichi
Department of Cardiology and Hematology, Fukushima Medical University
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Miyata Makiko
Department Of Cardiology And Hematology Fukushima Medical University
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Yoshihisa Akiomi
Department Of Advanced Cardiac Therapeutics Fukushima Medical University
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Takeishi Yasuchika
Department Of Advanced Cardiac Therapeutics Fukushima Medical University
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Nakazato Kazuhiko
Department Of Cardiology And Hematology Fukushima Medical University
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Kunii Hiroyuki
Department Of Cardiology And Hematology Fukushima Medical University
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Hoshino Yasuto
Department of Cardiology and Hematology, Fukushima Medical University
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Sato Takamasa
Department of Cardiology and Hematology, Fukushima Medical University
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SUZUKI SATOSHI
Department of Cardiology and Hematology, Fukushima Medical University
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OWADA TAKASHI
Department of Cardiology and Hematology, Fukushima Medical University
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SUGIMOTO Koichi
Department of Aeronautics and Astronautics, Faculty of Engineering Kyushu University
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Saitoh Shu-ichi
Department of Advanced Cardiac Therapeutics, Fukushima Medical University
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