PJ-582 Intravenous administration of statin prevents RhoA activation-triggered eNOS downregulation and reactive oxygen species induced by thrombin in rats(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2004-03-01

著者

• Ishibashi Toshiyuki

  First department of internal medicine, Fukushima Medical University

• Sugimoto Koichi

  First Department of Internal Medicine, Fukushima Medical University

• Ohkawara Hiroshi

  First Department of Internal Medicine, Fukushima Medical University

• Takuwa Yo

  Department Of Molecular And Cellular Physiology Kanazawa University Graduate School Of Medical Scien

• Ohkawara Hiroshi

  First Department Of Internal Medicine Fukushima Medical University

• Ishibashi Toshiyuki

  First Department Of Internal Medicine Fukushima Medical University

• Sugimoto Koichi

  Department Of Cardiology And Hematology Fukushima Medical University

• Sakamoto Takayuki

  First Department of Internal Medicine, Fukushima Medical University

• Yokoyama Keiko

  First Department of Internal Medicine, Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical University

• Yokoyama Keiko

  First Department Of Internal Medicine Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical College

• Takuwa Yoh

  Depatment of Physiology, Kanazawa University School of Medicine

• Sugimoto Koichi

  Cardiology Center Hoshi General Hospital

• Sakamoto Takayuki

  First Department Of Internal Medicine Fukushima Medical University

• Sugimoto Koichi

  First Department Of Internal Medicine Fukushima Medical University

• Sugimoto Koichi

  Department Of Cardiology Hoshi General Hospital

• Ishibashi Toshiyuki

  First Department Of Fumusima Medical University

関連論文

• PJ-127 Initial Result of Retrograde Approach for Chronic Total Occlusion (CTO) Lesions of Coronary Artery Disease(PJ021,Coronary Revascularization, PCI (Complex Lesions) (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
• OE-296 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Adenosine 5'-diphosphate, and Angiotensin(OE50,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (English),The 73rd Annual Scientific M
• Attenuation of Cardioprotective Effect by Postconditioning in Coronary Stenosed Rat Heart and Its Restoration by Carvedilol
• PJ-294 Quantitative Analysis of Change in Early Diastolic Strain Rate for Exercise Induced Myocardial Ischemia: Comparison with TC^ Myocardial Scintigraphy(Echo/Doppler(14)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PJ-059 Single Sirolimus-Eluting Stent Implantation after Directional Coronary Atherectomy for Left Main Bifurcation Lesions(Coronary revascularization, PCI(16)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation So
• PE-533 Short-term Cholesterol-lowering Therapy Improves Myocardial Microvascular Dysfunction in Patients with Hypercholesterolemia : Evaluation of Myocardial Blood Velocity by Myocardial Contrast Echocardiography(Echo/Doppler(10)(I),Poster Session(English
• PE-388 Atorvastatin Blocks an Advanced Glycation End Products (AGE) : Receptor for AGE(RAGE) Axis in Diabeteic Vascular Responses(Cardiovascular pharmacology, basic/clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
• PE-086 New Insights into Oxidized LDL-induced RhoA and Rac1 Activation by an LOX-1-MT1-MMP Axis in Endothelial Dysfunction(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-248 New Developed Powerful Tool for Detecting of Exercise Induced Myocardial Dysfunction : Assessment of Early Diastolic Strain Rate(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
• Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis
• Prediction of Remote Left Ventricular Volumes and Functions After Acute Myocardial Infarction With Successful Coronary Intervention
• DPJ-072 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha1-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(DPJ12,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Digital Poster Session (Japanese),The 73rd
• Unexpected Worsening of Mitral Regurgitation After Surgical Closure of Atrial Septal Defect
• Involvement of von Willebrand Factor and PGI_2 in Platelet Binding to a Partially Denuded Endothelial Monolayer
• RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits
• PE-493 Rapid Improvement of Impaired Endothelium-Dependent Vasodilation and Rac1/NADPH Oxidase-Derived ROS Generation in Vivo by Pravastatin(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd
• OE-091 Involvement of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Advanced Glycation End Products (AGE)/RAGE-Signaling Pathways(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-664 LOX-1 plays a crucial role in RhoA-and Rac1-dependent signaling through Gi induced by oxidized low-density lipoprotein in endothelial cells(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-559 Pravastatin Rapidly Prevents Thrombin-induced Vasoconstriction and NADPH Oxidase-dependent ROS Generation in vivo : Implications for Beneficial Effect(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese
• PJ-216 Receptor for Advanced Glycation End Products (RAGE) Plays a Crucial Role in Atherosclerosis(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-067 New Insights into Regulation of Diabetic Vascular Remodeling by an MT1-MMP-RAGE axis(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-197 RhoA-Dependent PAI-1 Gene Exprssion Induced in Endothelial Cells by Monocyte Adhesion is Mediated Via Geranylgeranyl Transferase I and Ca^ Signaling(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-475 Crucial Role of Geranylgeranyl Transferase I in AGE-Induced Gene Expression in Diabetes(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-473 A Novel Role of LOX-1 in Monocyte Adhesion-Induced Gene Expression via Redox-Sensitive and Ca^ Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
• PJ-102 MT1-MMP-RAGE Axis in Regulation of Advanced Glycation End Products (AGEs)-Dependent Redox-sensitive Signaling(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
• PE-003 Increased Expression of Matrix Metalloproteinase-9 and Apoptosis Induced by Advanced Glycation Endproducts in Type 2 Diabetes : Implications for Plaque Instability(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70t
• OJ-262 A Role of Reactive Oxygen Species in Coronary Spasm(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-164 Essential Role of Rapid Geranylgeranylation from Unprocessed RhoA in RhoA Activation and Increase in Unprocessed RhoA in Atherosclerosis(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Monocyte Adhesion to Endothelial Cells Activates p47phox/NF-kB via Renin-Angiotensin System(RAS), Resulting in Gene Induction of MCP-1, ICAM-1 and Tissue Factor (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulatio
• Activation of CCR2 by MCP-1 Accelerates TF Expression via Ca2+ Influx in Monocyte Adhesion to Nitric Oxide (NO)-Impaired Endothelial Cells(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Blockade of Renin-angiotensin System (RAS) Inhibits Oxidized LDL-induced Superoxide Generation by Suppressing NADPH Oxidase Component Nox-4, p47 phox and Rac(Atherosclerosis, Basic 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation So
• Membrane type 1 Metalloproteinase (MT1-MMP) is Involved in the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Hospital and Mid-Term Outcomes in Elderly Patients Undergoing Off-Pump Coronary Artery Bypass Grafting : Comparison With Younger Patients
• Role of Ca^ Influx in Tissue Factor Expression in Monocyte Adhesion to Endothelial Cells
• Inhibition of Matrix Metalloproteases (MMPs) Suppresses Rac/NADPH Oxidase-derived Reactive Oxygen Species (ROS) Generation in Oxidized Low Density Lipoprotein-stimuleted Endothelial Cells(Atherosclerosis, Basic 4 (IHD), The 69th Annual Scientific Meeting
• Therapeutic Effect of Intravenous Administration of Statin on eNOS Downregulation and ROS Generation in Response to Thrombin in Vivo(Cardiovascular Pharmacology, Basic/Clinical 2 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-582 Intravenous administration of statin prevents RhoA activation-triggered eNOS downregulation and reactive oxygen species induced by thrombin in rats(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• PE-216 Mechanism and Role of Geranylgeranylation in RhoA Activation in Endothelial Dysfunction(Metabolism/Biochemistry/Energetics 1 (IHD) : PE37)(Poster Session (English))
• OE-118 Inhibition of Matrix Metalloproteinases (MMPs) Suppresses the RhoA-dependent eNOS Downergulation Induced by Oxidized LDL in Endothelial Cells(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
• Rho Activation and Extracellular Signal-Regulated Kinase (ERK) Downregulation Are Crucial for eNOS Downregulation in Monocyte Adhesion to Endothelial Cells
• Thrombin-lnduced Downregulation of Endothelial Nitric Oxide Synthase (eNOS) via Rho Activation in Human Endothelial Cells :Involvement of Geranylgeranyl Transferase Activation
• Thrombin-Stimulated Ca^ Signaling Mediated via RhoA Activationin Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) Synthesis in Endothelial Cells
• RhoA Activation Plays an Integral Role in Tissue Factor (TF) Gene Expression
• Oxidized LDL Downregulates Endothelial Nitric Oxide Synthase (eNOS) via Rapid RhoA Activaion in Endothelial Cells
• OE-073 Quantitative Analysis of Change in Early Diastolic Strain Rate for Adenosine-Induced Myocardial Dysfunction(OE13,Echo/Doppler (New Technology) (I),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PE-322 SPECT/CTCA Fusion Image is Useful for the Diagnosis of Coronary Artery Stenosis with Calcification(PE054,CT/MRI (New Technology) (I),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• DPJ-024 Serum NT-proBNP Level for Diagnosis of Diastolic Heart Failure in Japanese Population(DPJ04,Heart Failure (Diagnosis) (M),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• OE-027 Adaptive Servo Ventilation Improves Cardiac Function in Heart Failure Patients with Cheyne-Stokes Respiration(OE05,Obesity/SAS (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• Role of Advanced Glycation End Products (AGEs) in Increased Matrix Metalloproteinases (MMPs) Expression in Patients with Diabetes Mellitus (DM)(Diabetes/Obesity 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-039 Correlation between Atherosclerotic Plaque Instability and Matrix Metalloproteinase(MMPs) Expression in Autopsy Cases of Diabetes Mellitus(DM)(Diabetes/Obesity 1 (H) : OJ5)(Oral Presentation (Japanese))
• FLOW-MEDIATED DILATATION IDENTIFIES IMPAIRED ENDOTHELIAL FUNCTION IN PATIENTS WITH SLEEP APNEA SYNDROME
• PJ-833 Assessment of Left Atrial Function : Comparison of MDCT and Echocardiography(CT / DSA(11)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-252 Metabolic Regulation of Coronary Vascular Tone : Role of Hydrogen Peroxide, Purinergic Component, and Angiotensin.(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
• PJ-248 Regulation of Coronary Vascular Tone via Redox Modulation in the Alpha-Adrenergic-Angiotensin-Endothelin Axis of the Myocardium(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PE-067 Comparative Analysis of the Incidence of Metabolic Syndrome among Different Age Groups in the Patients with Coronary Artery Disease(Diabetes/Obesity/Metabolic syndrome(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanes
• PJ-217 Monocyte Adhesion Induces Gene Expression Mediated via LOX-1-dependent Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-077 Detection of Myocardial Ischemia by Diastolic Myocardial Velocity Exercise Stress Echocardiography : Comparison with Exercise Stress Technetium-99m Myocardial Perfusion Scintigraphy(Echo / Doppler-04, The 71st Annual Scientific Meeting of the Japan
• Low Serum Ferritin Levels as a Clue to Colonic Cancer Detection in Two Patients with Coronary Artery Disease : A Case Report
• Extensive Patch Angioplasty of the Left Main Ostial Stenosis Using a Rhombic-Shaped Pulmonary Autograft
• 3P-057 レプリカ交換モンテカルロシミュレーションを用いた膜タンパク質の構造予測シミュレーション(蛋白質-物性(安定性,折れたたみなど),第47回日本生物物理学会年会)
• Expression of Cytokine and Adhesion Molecule mRNA in Atherectomy Specimens From Patients With Coronary Artery Disease
• IS112 Granulocyte-macrophage colony-stimulating factor alters cellular and extracellular composition of atherosclerotic lesions and reduces atherosclerosis in atherogenic rabbits
• OE-031 Characteristics of Hospitalized Heart Failure Patients Who Have Also Chronic Kidney Disease(Heart failure, clinical-01, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• Very low density lipoprotein receptor mRNA in monocytes is upregulated by hypoxia
• PJ-583 Pravastatin Inhibits the Generation of Reactive Oxygen Species Induced byThrombin in Endothelial Cells and Cardiomyocytes(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• OJ-217 Role of geranylgeranyl transferase activation and Ca^ Signaling in Plasminogen Activator Inhibitor-1 Expression in Endothelial Cells Triggered by Monocyte Adhesion(Blood Coagulation/Fibrinolysis (IHD) : OJ24)(Oral Presentation (Japanese))
• OJ-049 Nicorandil Suppresses Thrombin-induced Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 Expression (PAI-1) via Blockade of Ca^ influx in Endothelial Cells(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
• OE-274 HMG-CoA Reductase Inhibitor (Statin) Possibly Functions as Ca^ Antagonist in Endothelial Cells(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
• Blockade of Renin-Angiotensin System Downregulates TF in Monocyte Adhesion to Endothelial Cells via Suppressing ICAM-1, MCP-1 Expression and Ca^ Signaling
• Role of Hydrogen Peroxide (H_2O_2) on Non Selective Cation Current on Endothelial Cells Stimulated by Lysophosphatidylcholine (LPC)
• HMG-CoA Reductase Inhibitors (Statins) Suppress Nonselective Cation Current Induced by Lysophosphatidylcholine in Endothelial Cells
• Inhibition of Rho/Rho-kinase signaling rescues the downregulated eNOS synthesis induced by thrombin in endothelial cells
• Thrombin-stimulated Ca^ mobilization mediated via Gi through Rho/Rho-kinase is involved in tissue factor (TF) synthesis in endothelial cells (ECs)
• Comprehensive Analyses of Arrhythmogenic Substrates and Vulnerability to Ventricular Tachycardia in Left Ventricular Hypertrophy in Salt-Sensitive Hypertensive Rats
• Different Contribution of Apoptosis to the Antiproliferative Effects of L-Arginine, Enalapril and Losartan on Neointimal Growth Inhibition After Balloon Arterial Injury
• PE-208 Development of Decompensated Cardiac Hypertrophy in Transgenic Mice That Overexpress S1P1 under the Control of Alpha Smooth Muscle Actin Promoter(Cardiac hypertrophy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation
• PJ-366 Cyclic AMP-mediated Inhibitory Regulation of Rac Activation and Cell Migration by the EP2 subtype of Prostagalandin E2 (PGE2) Receptors in Vascular Smooth Muscle(Molecular Biology, Vascular 2 (H) : PJ61)(Poster Session (Japanese))
• Epstein-Barr Virus-Positive Hodgkin's Lymphoma in a Patient with Chronic Active Epstein-Barr Virus Infection
• Glomus tumor of the kidney
• PJ-009 Endothelin Type A Receptor Antagonist Has a Protective Effect on Coronary Microvascular Spasm Induced by Repeated Epicardial Endothelial Injury(Coronary circulation, basic/clinical-4 (IHD) PJ2,Poster Session (Japanese),The 70th Anniversary Annual S
• PJ-227 Different anti-ischemic heart failure effect of L-arginine or tetrahydrobiopterin and nitrate through their effects on ischemia-induced oxidative stress generation(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
• OJ-420 Protective effect of chronic endothelin type A receptor antagonist on coronary microvascular spasm induced by repeated epicardial endothelial injury.(Endothelium/NO 5 (H) : OJ51)(Oral Presentation (Japanese))
• FRS-068 Chronic endothelin type A receptor antagonist has a protective effect on coronary spasm induced by repeated epicardial endothelial injury.(Atherosclerosis (IHD) : FRS8)(Featured Research Session (English))
• THE INHIBITORY EFFECT OF ENALAPRIL ON THE NEOINTIMAL FORMATION AFTER ARTERIAL INTIMAL INJURY VIA APOPTOSIS
• Blockade of Endothelin-1 Prevents Coronary Spasm Induced by repeated Epicardial Endothelial Injury in a Pig Model (Endothelium/NO 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Chronic Endothelin Type A Antagonist is Effective to Prevent Coronary Microvascular Spasm Induced by Repeated Endothelial Injury(Coronary Circulation, Basic/Clinical 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• Effects of Granulocyte-Macrophage Colony-Stimulating Factor on the Levels of VLDL and LDL Receptor mRNAs in vivo
• A Study on Unsteady Flow Characteristics and Lateral Force of Conventional Bell-type Nozzle
• Plasmablastic lymphoma of the right testis
• Specificity of Vascular Reactivity and Remodeling After Repeated Endothelial Injury in a Swine Model
• Blockade of renin-angiotensin system downregulates tissue factor induced by monocyte-adhesion to endothelial cells via suppressing ICAM-1 and Ca^ signaling
• Inhibition of Rho and Rho-kinase downregulates the synthesis of tissue factor and plasminogen activator inhibitor-1 in cultured human monocytes
• Thoracic Epidural Angiolipoma : Case Report
• Rho activation plays a role in hydrogen peroxide production induced by lysophosphatidylcholine
• Endothelial dysfunction accompanied with Rho activation in thrombin-stimulation and its prevention by statin in vivo in rats
• Rapid activation of Rho is involved in intracellular Ca^ mobilization via phospholipase C in lysophosphatidylcholine-stimulated endothelial cells
• 'A Single Night' Beneficial Effects of Adaptive Servo-Ventilation on Cardiac Overload, Sympathetic Nervous Activity, and Myocardial Damage in Patients With Chronic Heart Failure and Sleep-Disordered Breathing
• L-NAME accelerates the synthesis of tissue factor and plasminogen activator inhibitor-i via MCP-1 in co-culture of endothelial cells and monocytes
• Monocyte-adhesion to endothelial cells impairs eNOS synthesis via activation of Rho and downregulation of extracellular signal-regulated kinase (ERK)
• Relationship between Excess Ga and Residual Oxides in Amorphous GaN Films Deposited by Compound Source Molecular Beam Epitaxy

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