Endothelial dysfunction accompanied with Rho activation in thrombin-stimulation and its prevention by statin in vivo in rats

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概要

• 論文の詳細を見る
• 社団法人日本循環器学会の論文
• 2002-03-31

著者

• Ohkawara Hiroshi

  First Department Of Internal Medicine Fukushima Medical University

• Sakamoto Takayuki

  First Department of Internal Medicine, Fukushima Medical University

• Yokoyama Keiko

  First Department of Internal Medicine, Fukushima Medical University

• Yokoyama Keiko

  First Department Of Internal Medicine Fukushima Medical University

• Maruyama Yukio

  First Department Of Internal Medicine Fukushima Medical College

• Ookawara Hiroshi

  First Department of Internal Medicine, Fukushima Medical University

• Sakamoto Takayuki

  First Department Of Internal Medicine Fukushima Medical University

• Sugimoto Koichi

  First Department Of Internal Medicine Fukushima Medical University

• Ishibashi Toshiyuki

  First Department Of Fumusima Medical University

関連論文

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• PJ-294 Quantitative Analysis of Change in Early Diastolic Strain Rate for Exercise Induced Myocardial Ischemia: Comparison with TC^ Myocardial Scintigraphy(Echo/Doppler(14)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanes
• PE-533 Short-term Cholesterol-lowering Therapy Improves Myocardial Microvascular Dysfunction in Patients with Hypercholesterolemia : Evaluation of Myocardial Blood Velocity by Myocardial Contrast Echocardiography(Echo/Doppler(10)(I),Poster Session(English
• PE-388 Atorvastatin Blocks an Advanced Glycation End Products (AGE) : Receptor for AGE(RAGE) Axis in Diabeteic Vascular Responses(Cardiovascular pharmacology, basic/clinical(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
• PE-086 New Insights into Oxidized LDL-induced RhoA and Rac1 Activation by an LOX-1-MT1-MMP Axis in Endothelial Dysfunction(Endothelium(02)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-248 New Developed Powerful Tool for Detecting of Exercise Induced Myocardial Dysfunction : Assessment of Early Diastolic Strain Rate(Echo / Doppler(04)(I),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Socie
• Attenuation of Diastolic Heart Failure and Life-Threatening Ventricular Tachyarrhythmia After Peripheral Blood Stem Cell Transplantation Combined With Cardioverter-Defibrillator Implantation in Myeloma-Associated Cardiac Amyloidosis
• Prediction of Remote Left Ventricular Volumes and Functions After Acute Myocardial Infarction With Successful Coronary Intervention
• Unexpected Worsening of Mitral Regurgitation After Surgical Closure of Atrial Septal Defect
• Involvement of von Willebrand Factor and PGI_2 in Platelet Binding to a Partially Denuded Endothelial Monolayer
• RhoA and Rac1 Changes in the Atherosclerotic Lesions of WHHLMI Rabbits
• PE-493 Rapid Improvement of Impaired Endothelium-Dependent Vasodilation and Rac1/NADPH Oxidase-Derived ROS Generation in Vivo by Pravastatin(PE083,Cardiovascular Pharmacology (Basic), Cost-health Care System/DPC/Laws (H),Poster Session (English),The 73rd
• OE-091 Involvement of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) in Advanced Glycation End Products (AGE)/RAGE-Signaling Pathways(OE16,Diabetes (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-664 LOX-1 plays a crucial role in RhoA-and Rac1-dependent signaling through Gi induced by oxidized low-density lipoprotein in endothelial cells(Molecular biology, vascular-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-559 Pravastatin Rapidly Prevents Thrombin-induced Vasoconstriction and NADPH Oxidase-dependent ROS Generation in vivo : Implications for Beneficial Effect(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese
• PJ-216 Receptor for Advanced Glycation End Products (RAGE) Plays a Crucial Role in Atherosclerosis(Atherosclerosis, basic-9, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-067 New Insights into Regulation of Diabetic Vascular Remodeling by an MT1-MMP-RAGE axis(Atherosclerosis, basic-8, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-197 RhoA-Dependent PAI-1 Gene Exprssion Induced in Endothelial Cells by Monocyte Adhesion is Mediated Via Geranylgeranyl Transferase I and Ca^ Signaling(Atherosclerosis, basic-3, The 71st Annual Scientific Meeting of the Japanese Circulation Societ
• PJ-475 Crucial Role of Geranylgeranyl Transferase I in AGE-Induced Gene Expression in Diabetes(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• PJ-473 A Novel Role of LOX-1 in Monocyte Adhesion-Induced Gene Expression via Redox-Sensitive and Ca^ Signaling Pathways in Endothelial Cells(Atherosclerosis, basic-5 (H) PJ80,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
• PJ-102 MT1-MMP-RAGE Axis in Regulation of Advanced Glycation End Products (AGEs)-Dependent Redox-sensitive Signaling(Molecular biology, vascular-3 (H) PJ17,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulatio
• PE-003 Increased Expression of Matrix Metalloproteinase-9 and Apoptosis Induced by Advanced Glycation Endproducts in Type 2 Diabetes : Implications for Plaque Instability(Acute coronary syndrome, basic/clinical-4 (IHD) PE1,Poster Session (English),The 70t
• OJ-262 A Role of Reactive Oxygen Species in Coronary Spasm(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-164 Essential Role of Rapid Geranylgeranylation from Unprocessed RhoA in RhoA Activation and Increase in Unprocessed RhoA in Atherosclerosis(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
• Monocyte Adhesion to Endothelial Cells Activates p47phox/NF-kB via Renin-Angiotensin System(RAS), Resulting in Gene Induction of MCP-1, ICAM-1 and Tissue Factor (Atherosclerosis, Basic 9 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulatio
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• OJ-275 Improvement of Microvascural Dysfunction by Cholesterol-lowering Therapy in Patients with Hypercholesterolemia is Different between Forearm and Coronary Arterial Beds(Echo/Doppler-5 (I) OJ46,Oral Presentation (Japanese),The 70th Anniversary Annual
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• Role of Advanced Glycation End Products (AGEs) in Increased Matrix Metalloproteinases (MMPs) Expression in Patients with Diabetes Mellitus (DM)(Diabetes/Obesity 9 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
• OJ-039 Correlation between Atherosclerotic Plaque Instability and Matrix Metalloproteinase(MMPs) Expression in Autopsy Cases of Diabetes Mellitus(DM)(Diabetes/Obesity 1 (H) : OJ5)(Oral Presentation (Japanese))
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• Atherosclerotic plaque instability and the structural differenceof myocyte in autopsy case of diabetes mellitus
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• PJ-788 Scintigraphic Predictors of Remote Left Ventricular Volumes and Function in Acute Myocardial Infarction with Successful Reperfusion(Nuclear cardiology-9 (H) PJ138,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japan
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• PE-270 Hypercholesterolemia Attenuates Cardioprotective Effect of Postconditioning in Association with Endothelial Nitric Oxide Dysfunction in Rat Acute Myocardial Infarction(Myocardial ischemia-reperfusion, basic/clinical-4 (IHD) PE45,Poster Session (Eng
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• Very low density lipoprotein receptor mRNA in monocytes is upregulated by hypoxia
• PJ-583 Pravastatin Inhibits the Generation of Reactive Oxygen Species Induced byThrombin in Endothelial Cells and Cardiomyocytes(Cardiovascular Pharmacology, Basic/Clinical 5 (H) : PJ98)(Poster Session (Japanese))
• OJ-217 Role of geranylgeranyl transferase activation and Ca^ Signaling in Plasminogen Activator Inhibitor-1 Expression in Endothelial Cells Triggered by Monocyte Adhesion(Blood Coagulation/Fibrinolysis (IHD) : OJ24)(Oral Presentation (Japanese))
• OJ-049 Nicorandil Suppresses Thrombin-induced Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 Expression (PAI-1) via Blockade of Ca^ influx in Endothelial Cells(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
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• Inhibition of Rho and Rho-kinase downregulates the synthesis of tissue factor and plasminogen activator inhibitor-1 in cultured human monocytes
• Rho activation plays a role in hydrogen peroxide production induced by lysophosphatidylcholine
• Endothelial dysfunction accompanied with Rho activation in thrombin-stimulation and its prevention by statin in vivo in rats
• Rapid activation of Rho is involved in intracellular Ca^ mobilization via phospholipase C in lysophosphatidylcholine-stimulated endothelial cells
• L-NAME accelerates the synthesis of tissue factor and plasminogen activator inhibitor-i via MCP-1 in co-culture of endothelial cells and monocytes
• Monocyte-adhesion to endothelial cells impairs eNOS synthesis via activation of Rho and downregulation of extracellular signal-regulated kinase (ERK)

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